Multiple Resistance Mechanisms to Pyrethroids Insecticides in Anopheles gambiae sensu lato Population From Mali, West Africa
| Autor: | Boubacar Coulibaly, Boïssé Traoré, Seydou Doumbia, Ambiélè Bernard Sodio, Francis Zeukeng, Moussa Keita, Sekou F. Traore, Nafomon Sogoba, Rousseau Djouaka, Fousseyni Kané |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Piperonyl butoxide Insecticides Mosquito Control Anopheles gambiae 030231 tropical medicine Population Zoology Mosquito Vectors Mali Insecticide Resistance 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine pyrethroids parasitic diseases Anopheles Pyrethrins medicine Immunology and Allergy Animals education education.field_of_study biology Knockdown resistance biology.organism_classification 030104 developmental biology Infectious Diseases Deltamethrin AcademicSubjects/MED00290 chemistry Vector (epidemiology) Supplement Article geographic locations A gambiae s.l Permethrin medicine.drug |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background Insecticide-based vector control is responsible for reducing malaria mortality and morbidity. Its success depends on a better knowledge of the vector, its distribution, and resistance status to the insecticides used. In this paper, we assessed Anopheles gambiae sensu lato (A gambiae s.l.) population resistance to pyrethroids in different ecological settings. Methods The World Health Organization standard bioassay test was used to assess F0A gambiae s.l. susceptibility to pyrethroids. Biochemical Synergist assays were conducted with piperonyl butoxide (PBO), S,S,S-tributyl phosphotritioate, and diethyl maleate. L1014F, L1014S, and N1575Y knockdown resistance (kdr) mutations were investigated using TaqMan genotyping. Results Anopheles gambiae sensu lato was composed of Anopheles arabienisis, Anopheles coluzzii, and A gambiae in all study sites. Anopheles gambiae sensu lato showed a strong phenotypic resistance to deltamethrin and permethrin in all sites (13% to 41% mortality). In many sites, pre-exposure to synergists partially improved the mortality rate suggesting the presence of detoxifying enzymes. The 3 kdr (L1014F, L1014S, and N1575Y) mutations were found, with a predominance of L1014F, in all species. Conclusions Multiple resistance mechanisms to pyrethroids were observed in A gambiae s.l. in Mali. The PBO provided a better partial restoration of susceptibility to pyrethroids, suggesting that the efficacy of long-lasting insecticidal nets may be improved with PBO. |
| Databáze: | OpenAIRE |
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