Chronic thromboembolic pulmonary hypertension suspicion after pulmonary embolism in cancer patients
| Autor: | Judith Catella-Chatron, E. De Magalhaes, Patrick Mismetti, Adel Merah, Nathalie Moulin, Laurent Bertoletti, Sandrine Accassat, Cécile Duvillard |
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| Přispěvatelé: | Biologie intégrative du tissu osseux, Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Etienne, Université Jean Monnet - Saint-Étienne (UJM), CIC Saint Etienne, Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Nord (Saint Etienne), INSERM U1059, SAINBIOSE - Santé, Ingénierie, Biologie, Saint-Etienne (SAINBIOSE-ENSMSE), Centre Ingénierie et Santé (CIS-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), CCSD, Accord Elsevier |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
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Pulmonary and Respiratory Medicine medicine.medical_specialty Epidemiology Colorectal cancer Hypertension Pulmonary [SDV]Life Sciences [q-bio] Chronic thromboembolic pulmonary hypertension 030204 cardiovascular system & hematology 03 medical and health sciences Prostate cancer 0302 clinical medicine Breast cancer Risk Factors Neoplasms Internal medicine medicine Humans Registries Cancer Aged Retrospective Studies Aged 80 and over business.industry Incidence Incidence (epidemiology) Venous Thromboembolism Middle Aged medicine.disease 3. Good health Pulmonary embolism [SDV] Life Sciences [q-bio] 030220 oncology & carcinogenesis Concomitant Chronic Disease Female France Pulmonary Embolism Ovarian cancer business |
| Zdroj: | Respiratory Medicine and Research Respiratory Medicine and Research, Elsevier, 2019, 76, pp.34-37. ⟨10.1016/j.resmer.2019.08.002⟩ Respiratory Medicine and Research, 2019, 76, pp.34-37. ⟨10.1016/j.resmer.2019.08.002⟩ |
| ISSN: | 2590-0412 |
| Popis: | International audience; Introduction: Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe condition which should be screened in patient with persistent dyspnea after pulmonary embolism (PE). After PE, CTEPH incidence was estimated between 0.1 and 9.1% in overall patients. Although cancer is associated with an increased risk of CTEPH, CTEPH incidence is still unknown in cancer patients with PE. We aimed to estimate the frequency CTEPH-likely patients after PE, in cancer patients.Materials: We individualized cancer patients of a monocentric prospective registry including consecutive patients with symptomatic PE. The primary outcome was the frequency of "CTEPH-likely" patients defined by the European Respiratory Society (ERS) guidelines (an accelerated tricuspid regurgitation more than 2.8m/s and at least 1-2 segmental or larger-sized defects, after more than 3 months of therapeutic anticoagulation).Results: We included 129 cancer patients with PE. Colorectal cancer (19%), breast cancer (17%) and prostate cancer (15%) were the most frequent cancers. PE occurred after surgery or medical immobilization in 17% of patients, while 26% of patients had history of venous thromboembolism. During the follow-up, 2 patients (1.5%) had a clinical suspicion of CTEPH and only 1 patient with ovarian cancer (0.75% 95%CI [0.0%-2.2%]) was classified as "CTEPH-likely", 6 months after PE.Conclusion: The frequency of screening for CTEPH seems negligible in PE patients with cancer. Concomitant cancer may affect the clinical suspicion of CTEPH. |
| Databáze: | OpenAIRE |
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