Genomic characterization of two new enterovirus types, EV-A114 and EV-A121
| Autor: | Vinay K. Saxena, Deepa K. Sharma, Uma P. Nalavade, Jagadish M. Deshpande, Sushmitha A. Shetty, Tarique Husain I. H. Qureshi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Male Sequence analysis viruses India Genome Viral Biology medicine.disease_cause Microbiology Genome Virus 03 medical and health sciences Feces Species Specificity Phylogenetics medicine Enterovirus Infections Humans Phylogeny Viral Structural Proteins Phylogenetic tree Nucleic acid sequence virus diseases Infant General Medicine Sequence Analysis DNA Virology Enterovirus A Human Enterovirus B Human Genus Enterovirus 030104 developmental biology Child Preschool Enterovirus RNA Viral Female Sequence Alignment |
| Zdroj: | Journal of medical microbiology. 65(12) |
| ISSN: | 1473-5644 |
| Popis: | Enteroviruses cause a variety of illnesses of the gastrointestinal tract, central nervous system and cardiovascular system. Phylogenetic analysis of VP1 sequences has identified 106 different human enteroviruses classified into four enterovirus species within the genus Enterovirus of the family Picornaviridae. It is likely that not all enterovirus types have been discovered. Between September 2013 and October 2014, stool samples of 6274 apparently healthy children of up to 5 years of age residing in Gorakhpur district, Uttar Pradesh, India were screened for enteroviruses. Virus isolates obtained in RD and Hep-2c cells were identified by complete VP1 sequencing. Enteroviruses were isolated from 3042 samples. A total of 87 different enterovirus types were identified. Two isolates with 71 and 74 % nucleotide sequence similarity to all other known enteroviruses were recognized as novel types. In this paper we report identification and complete genome sequence analysis of these two isolates classified as EV-A114 and EV-A121. |
| Databáze: | OpenAIRE |
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