Norovirus gastroenteritis in young children receiving human rotavirus vaccine
| Autor: | Anne Halkosalo, Aino Karvonen, Evelin D Szakal, Timo Vesikari, Shang-Qin Zeng, Marjo Salminen |
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| Rok vydání: | 2010 |
| Předmět: |
Microbiology (medical)
viruses Reoviridae medicine.disease_cause Placebo Vaccines Attenuated Virus Statistics Nonparametric Placebos fluids and secretions Rotavirus Medicine Humans Prospective Studies Caliciviridae Infections General Immunology and Microbiology biology business.industry Norovirus Rotavirus Vaccines virus diseases Infant General Medicine biology.organism_classification Rotavirus vaccine Virology Gastroenteritis Vaccination Infectious Diseases Immunization Acute Disease business |
| Zdroj: | Scandinavian journal of infectious diseases. 42(6-7) |
| ISSN: | 1651-1980 |
| Popis: | We explored whether human rotavirus vaccine had any efficacy against norovirus (NV)-associated gastroenteritis in young children. In an efficacy trial of rotavirus vaccine, 405 infants were immunized with a human rotavirus vaccine or placebo at a ratio of 2:1, and prospectively followed for acute gastroenteritis (AGE) from approximately 2 months to 2 y of age. Multiplex real-time reverse transcription polymerase chain reaction (Mrt RT-PCR) assays were used for detection and quantitation of NVs of genogroup I (GI) and genogroup II (GII) in stool specimens. NVs were detected in 155 (32%) of 485 episodes of AGE. Of these, NV was the only gastroenteritis virus detected in the stools in 142 (29%) episodes. GI and GII NVs were found in 12% and 88% of the cases, respectively. NV as the only gastroenteritis virus was detected in 36% of the infants in the rotavirus vaccine group and 27% in the placebo group. The clinical severity of NV-associated AGE in the vaccine and placebo recipients was not different. NVs were the most common etiologic agents of AGE in children under 2 y of age. Human rotavirus vaccine did not protect against NV gastroenteritis. |
| Databáze: | OpenAIRE |
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