Association of Leukocyte Activation, but Not the Common Cold, with Restenosis after Percutaneous Coronary Intervention in Patients with Angina Pectoris
| Autor: | N. Takahashi, Kohichi Yamada, T Iwasaka, S. Nomura, Hisato Nakamori, Y Sutani, Yutaka Kimura, Norihito Inami, S Fukuhara, Nobuyuki Tsuda |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Antibiotics Common Cold Balloon Angina Pectoris Coronary Restenosis Angina Restenosis Physiology (medical) Angioplasty Internal medicine Leukocytes medicine Humans cardiovascular diseases Angioplasty Balloon Coronary L-Selectin Aged business.industry Percutaneous coronary intervention Common cold Hematology Middle Aged medicine.disease surgical procedures operative Conventional PCI Cardiology Female business |
| Zdroj: | Pathophysiology of Haemostasis and Thrombosis. 34:13-17 |
| ISSN: | 1424-8840 1424-8832 |
| Popis: | We investigated the relationship between the common cold and restenosis after percutaneous coronary intervention (PCI) in Japanese patients with angina pectoris, because suffering from a common cold during the follow-up period after PCI may be involved in the development of restenosis. In addition, we measured the soluble (s) L-selectin level early after PCI in patients with and without restenosis. The study group included 104 effort angina pectoris patients. We examined whether or not they had had a common cold in the 6 months following angioplasty. Finally, 88 patients, whose common cold status was known, were selected as the study subjects. Twelve patients caught a common cold after PCI. All of these patients were given antibiotics and/or anti-inflammatory agents and recovered within 2 weeks. None had clinically detectable influenza infection. Thirty-three patients suffered from restenosis and 55 did not. There was no significant difference in the restenosis frequency between effort angina pectoris patients with and without a common cold. The sL-selectin level was significantly increased in patients with restenosis early after PCI, whereas in patients without restenosis, sL-selectin remained unchanged. These findings suggest that restenosis development after PCI in patients with effort angina pectoris may involve leukocyte activation early after PCI, while suffering from a common cold during the follow-up period after PCI has no effect. |
| Databáze: | OpenAIRE |
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