HIV-1 Transmission During Recent Infection and During Treatment Interruptions as Major Drivers of New Infections in the Swiss HIV Cohort Study

Autor: Alex, Marzel, Mohaned, Shilaih, Wan-Lin, Yang, Jürg, Böni, Sabine, Yerly, Thomas, Klimkait, Vincent, Aubert, Dominique L, Braun, Alexandra, Calmy, Hansjakob, Furrer, Matthias, Cavassini, Manuel, Battegay, Pietro L, Vernazza, Enos, Bernasconi, Huldrych F, Günthard, Roger D, Kouyos, V, Aubert, M, Battegay, E, Bernasconi, J, Böni, H C, Bucher, C, Burton-Jeangros, A, Calmy, M, Cavassini, G, Dollenmaier, M, Egger, L, Elzi, J, Fehr, J, Fellay, H, Furrer, C A, Fux, M, Gorgievski, H F, Günthard, D, Haerry, B, Hasse, H H, Hirsch, M, Hoffmann, I, Hösli, C, Kahlert, L, Kaiser, O, Keiser, T, Klimkait, R D, Kouyos, H, Kovari, B, Ledergerber, G, Martinetti, B Martinez, de Tejada, K, Metzner, N, Müller, D, Nadal, D, Nicca, G, Pantaleo, A, Rauch, S, Regenass, M, Rickenbach, C, Rudin, F, Schöni-Affolter, P, Schmid, J, Schüpbach, R, Speck, P, Tarr, A, Trkola, P L, Vernazza, R, Weber, S, Yerly
Přispěvatelé: Marzel, Alex, Shilaih, Mohaned, Yang, Wan-Lin, Böni, Jürg, Yerly Ferrillo, Sabine, Klimkait, Thomas, Aubert, Vincent, Braun, Dominique L, Calmy, Alexandra, Furrer, Hansjakob, Cavassini, Matthias, Battegay, Manuel, Vernazza, Pietro L, Bernasconi, Enos, Günthard, Huldrych F, Kouyos, Roger D, Burton-Jeangros, Claudine, Kaiser, Laurent, Keiser, Olivia
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Clinical Infectious Diseases, Vol. 62, No 1 (2016) pp. 115-122
Marzel, Alex; Shilaih, Mohaned; Yang, Wan-Lin; Böni, Jürg; Yerly, Sabine; Klimkait, Thomas; Aubert, Vincent; Braun, Dominique L; Calmy, Alexandra; Furrer, Hansjakob; Cavassini, Matthias; Battegay, Manuel; Vernazza, Pietro L; Bernasconi, Enos; Günthard, Huldrych F; Kouyos, Roger D (2016). HIV-1 Transmission During Recent Infection and During Treatment Interruptions as Major Drivers of New Infections in the Swiss HIV Cohort Study. Clinical infectious diseases, 62(1), pp. 115-122. Oxford University Press 10.1093/cid/civ732
ISSN: 1058-4838
Popis: BACKGROUND Reducing the fraction of transmissions during recent human immunodeficiency virus (HIV) infection is essential for the population-level success of "treatment as prevention". METHODS A phylogenetic tree was constructed with 19 604 Swiss sequences and 90 994 non-Swiss background sequences. Swiss transmission pairs were identified using 104 combinations of genetic distance (1%-2.5%) and bootstrap (50%-100%) thresholds, to examine the effect of those criteria. Monophyletic pairs were classified as recent or chronic transmission based on the time interval between estimated seroconversion dates. Logistic regression with adjustment for clinical and demographic characteristics was used to identify risk factors associated with transmission during recent or chronic infection. FINDINGS Seroconversion dates were estimated for 4079 patients on the phylogeny, and comprised between 71 (distance, 1%; bootstrap, 100%) to 378 transmission pairs (distance, 2.5%; bootstrap, 50%). We found that 43.7% (range, 41%-56%) of the transmissions occurred during the first year of infection. Stricter phylogenetic definition of transmission pairs was associated with higher recent-phase transmission fraction. Chronic-phase viral load area under the curve (adjusted odds ratio, 3; 95% confidence interval, 1.64-5.48) and time to antiretroviral therapy (ART) start (adjusted odds ratio 1.4/y; 1.11-1.77) were associated with chronic-phase transmission as opposed to recent transmission. Importantly, at least 14% of the chronic-phase transmission events occurred after the transmitter had interrupted ART. CONCLUSIONS We demonstrate a high fraction of transmission during recent HIV infection but also chronic transmissions after interruption of ART in Switzerland. Both represent key issues for treatment as prevention and underline the importance of early diagnosis and of early and continuous treatment.
Databáze: OpenAIRE
Externí odkaz: