Synthesis of novel poly(ethylene glycol) supported benzazepines, the crucial role of PEG on the selectivity of an intramolecular Heck reaction
| Autor: | Jean Martinez, Yannig Nedellec, Valérie Declerck, Frédéric Lamaty, Patrice Ribière, Neerja Yadav-Bhatnagar |
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| Přispěvatelé: | Laboratoire des Agrégats Moléculaires et Matériaux Inorganiques (LAMMI), Centre National de la Recherche Scientifique (CNRS)-Université Montpellier 2 - Sciences et Techniques (UM2), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Aventis Pharma, Aventis, Laboratoire des Amino-acides Peptides et Protéines (LAPP), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), laboratoire de chimie et pharmacologie de molécules d'intérêt biologique |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
inorganic chemicals
Poly ethylene glycol Benzazepines chemistry.chemical_element macromolecular substances 010402 general chemistry 01 natural sciences Biochemistry chemistry.chemical_compound Heck reaction Polymer chemistry Drug Discovery PEG ratio ComputingMilieux_MISCELLANEOUS 010405 organic chemistry Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Organic Chemistry technology industry and agriculture Palladium nanoparticles General Medicine [CHIM.MATE]Chemical Sciences/Material chemistry Combinatorial chemistry 0104 chemical sciences Intramolecular force Solvent effects Selectivity Ethylene glycol Palladium |
| Zdroj: | Tetrahedron Tetrahedron, Elsevier, 2006, 62, pp.10456-10466. ⟨10.1016/j.tet.2006.08.009⟩ |
| ISSN: | 0040-4020 |
| DOI: | 10.1016/j.tet.2006.08.009⟩ |
| Popis: | Poly(ethylene glycol) (PEG 3400) was used as a soluble polymeric support for the synthesis of a series of novel benzazepines. The key step for the preparation of these heterocycles was a phosphine-free palladium-catalyzed Heck reaction. Palladium nanoparticles formed during the course of the reaction were characterized. The presence of PEG 3400 influenced the outcome of the reaction in terms of selectivity. |
| Databáze: | OpenAIRE |
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