Fatigue and sleepiness determine respiratory quality of life among veterans evaluated for sleep apnea

Autor: Denis Vinnikov, Paul D. Blanc, Jon-Erik C Holty, Alaena Alilin, Moshe Zutler
Jazyk: angličtina
Předmět:
Quality of life
Adult
Male
medicine.medical_specialty
Polysomnography
Excessive daytime sleepiness
Comorbidity
Chronic obstructive
03 medical and health sciences
0302 clinical medicine
Surveys and Questionnaires
medicine
Humans
Disorders of excessive somnolence
Lung diseases
Fatigue
Sleep apnea syndromes
Aged
Veterans
2. Zero hunger
Sleep Apnea
Obstructive
medicine.diagnostic_test
business.industry
Epworth Sleepiness Scale
Research
Public Health
Environmental and Occupational Health
Sleep apnea
General Medicine
Middle Aged
medicine.disease
Health status indicators
Asthma
humanities
nervous system diseases
3. Good health
respiratory tract diseases
Obstructive sleep apnea
030228 respiratory system
Physical therapy
Female
medicine.symptom
Pulmonary disease
business
Body mass index
030217 neurology & neurosurgery
Zdroj: Health and Quality of Life Outcomes
ISSN: 1477-7525
DOI: 10.1186/s12955-017-0624-x
Popis: Background In those with symptoms indicative of obstructive sleep apnea (OSA), respiratory-specific health-related quality of life (HRQL) may be an important patient-centered outcome. The aim of this study was to assess the associations between sleepiness, fatigue, and impaired general and respiratory-specific HRQL among persons with suspected OSA. Methods We evaluated military veterans consecutively referred for suspected OSA with sleep studies yielding apnea-hypopnea index (AHI) values. They also completed the sleepiness (Epworth Sleepiness Scale [ESS]), and fatigue (Fatigue Severity Scale [FSS]) questionnaires, as well as two HRQL instruments (the generic Short-Form SF-12v2 yielding the Physical Component Scale [PCS] and the respiratory-specific Airways Questionnaire [AQ]-20R). Multiple linear regression tested the associations between ESS and FSS (standardized as Z scores for scaling comparability) with AQ-20R, accounting for AHI, SF-12v2-PCS and comorbid respiratory conditions other than OSA. Results We studied 1578 veterans (median age 61.1 [IQR 16.8] years; 93.9% males). Of these, 823 (52%) met AHI criteria for moderate to severe OSA (AHI ≥15/h). The majority reported excessive daytime sleepiness (53%; median ESS 11 [IQR 9]) or fatigue (61%; median FSS 42 [IQR 23]). The median AQ-20R was 4 [IQR 1–8]. Controlling for AHI, SF-12v2-PCS, respiratory co-morbid conditions, body mass index, and demographics, both ESS and FSS were significantly associated with poorer AQ-20R: for each; ESS, 1.6 points (95% CI 1.4–1.9), and for FSS, 2.5 points (95% CI, 2.3–2.7). Conclusions Greater daytime sleepiness and fatigue are associated with poorer respiratory-specific HRQL, over and above the effects of OSA, respiratory comorbidity, and generic physical HRQL.
Databáze: OpenAIRE
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