Cumulative Occupational Exposures and Lung Function Decline in Two Large General Population Cohorts
| Autor: | Josep M. Antó, Deborah Jarvis, Roberto Bono, Simona Villani, Dennis Nowak, Hayat Bentouhami, Jan Paul Zock, Bénédicte Leynaert, Theodore Lytras, Kjell Torén, Isabel Urrutia, Joachim Heinrich, Bertil Forsberg, Isabelle Pin, Joost Weyler, Chantal Raherison Semjen, Jesús Martínez-Moratalla, Vivi Schlünssen, Giulia Squillacioti, Dirk Keidel, Nicole Probst-Hensch, Øistein Svanes, Torben Sigsgaard, Rain Jõgi, Pascal Demoly, Mathias Holm, Paul D. Blanc, Antonio Pereira Vega, John Watkins, Mario Olivieri, Amar Mehta, Anne-Elie Carsin, Anna Beckmeyer-Borowko, David Vernez, Thorarinn Gislason, Dan Norbäck, Roel Vermeulen, José Antonio Gullón, Manolis Kogevinas, Geza Benke, A. Sonia Buist, Hans Kromhout |
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| Přispěvatelé: | Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), Swiss Tropical and Public Health Institute [Basel], University of Basel (Unibas), CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Utrecht University [Utrecht], University of Antwerp (UA), Klinikum der Universitat Munchen, Ludwig-Maximilians-Universität München (LMU), German Center for Lung Research, Galdakao Hospital, Complejo Hospitalario Universitario de Albacete, Universidad de Castilla-La Mancha = University of Castilla-La Mancha (UCLM), Hospital Juan Ramón Jiménez, Cancer environnement (EPICENE ), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de médecine aiguë spécialisée, CHU Grenoble-Hôpital Michallon, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut Desbrest de santé publique (IDESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Physiopathologie et Epidémiologie des Maladies Respiratoires (PHERE (UMR_S_1152 / U1152)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Università degli Studi di Pavia = University of Pavia (UNIPV), Landspitali National University Hospital of Iceland, University of Iceland [Reykjavik], University of Bergen (UiB), Sahlgrenska University Hospital [Gothenburg], Umeå University, Uppsala University, University of Copenhagen = Københavns Universitet (UCPH), Université de Lausanne = University of Lausanne (UNIL), Monash University [Melbourne], Tartu University Hospital [Tartu, Estonia], Sahlgrenska Academy at University of Gothenburg [Göteborg], Aarhus University [Aarhus], Università degli studi di Verona = University of Verona (UNIVR), University of California [San Francisco] (UC San Francisco), University of California (UC), Cardiff University, Università degli studi di Torino = University of Turin (UNITO), Oregon Health and Science University [Portland] (OHSU), Imperial College London, Herrada, Anthony |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
longitudinal studies
lung function occupational disease occupational exposure spirometry Vital Capacity Spirometry Lung function Occupational Exposure Occupational Disease Longitudinal studies VENTILATORY FUNCTION [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract MESH: Occupational Exposure Cohort Studies 0302 clinical medicine Forced Expiratory Volume Medicine 030212 general & internal medicine Lung MESH: Cohort Studies Original Research RISK education.field_of_study medicine.diagnostic_test WORKERS Occupational Diseases SWISS Occupational exposure BURDEN Adult MESH: Occupational Diseases Pulmonary and Respiratory Medicine MESH: Bayes Theorem Population AMERICAN THORACIC SOCIETY Occupational disease MEDLINE MESH: Forced Expiratory Volume OBSTRUCTIVE PULMONARY-DISEASE 03 medical and health sciences Environmental health Humans COPD MESH: Lung education MESH: Humans business.industry Bayes Theorem MESH: Adult AIR-POLLUTION MESH: Vital Capacity medicine.disease respiratory tract diseases 030228 respiratory system [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract Human medicine business FOLLOW-UP |
| Zdroj: | Lytras, T, Beckmeyer-Borowko, A, Kogevinas, M, Kromhout, H, Carsin, A-E, Antó, J M, Bentouhami, H, Weyler, J, Heinrich, J, Nowak, D, Urrutia, I, Martínez-Moratalla, J, Gullón, J A, Pereira Vega, A, Raherison Semjen, C, Pin, I, Demoly, P, Leynaert, B, Villani, S, Gislason, T, Svanes, Ø, Holm, M, Forsberg, B, Norbäck, D, Mehta, A J, Keidel, D, Vernez, D, Benke, G, Jõgi, R, Torén, K, Sigsgaard, T, Schlünssen, V, Olivieri, M, Blanc, P D, Watkins, J, Bono, R, Squillacioti, G, Buist, A S, Vermeulen, R, Jarvis, D, Probst-Hensch, N & Zock, J-P 2021, ' Cumulative Occupational Exposures and Lung Function Decline in Two Large General Population Cohorts ', Annals of the American Thoracic Society, vol. 18, no. 2, pp. 238–246 . https://doi.org/10.1513/AnnalsATS.202002-113OC Annals of the American Thoracic Society Annals of the American Thoracic Society, 2021, 18 (2), pp.238-246. ⟨10.1513/AnnalsATS.202002-113OC⟩ Ann Am Thorac Soc Proceedings of the American Thoracic Society |
| ISSN: | 2329-6933 2325-6621 1546-3222 |
| DOI: | 10.1513/AnnalsATS.202002-113OC |
| Popis: | International audience; Rationale: Few longitudinal studies have assessed the relationship between occupational exposures and lung-function decline in the general population with a sufficiently long follow-up.Objectives: To examine the potential association in two large cohorts: the ECRHS (European Community Respiratory Health Survey) and the SAPALDIA (Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults).Methods: General-population samples of individuals aged 18 to 62 were randomly selected in 1991-1993 and followed up approximately 10 and 20 years later. Spirometry (without bronchodilation) was performed at each visit. Coded complete job histories during follow-up visits were linked to a job-exposure matrix, generating cumulative exposure estimates for 12 occupational exposures. Forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were jointly modeled in linear mixed-effects models, fitted in a Bayesian framework, taking into account age and smoking.Results: A total of 40,024 lung-function measurements from 17,833 study participants were analyzed. We found accelerated declines in FEV1 and the FEV1/FVC ratio for exposure to biological dust, mineral dust, and metals (FEV1 = -15.1 ml, -14.4 ml, and -18.7 ml, respectively; and FEV1/FVC ratio = -0.52%, -0.43%, and -0.36%, respectively; per 25 intensity-years of exposure). These declines were comparable in magnitude with those associated with long-term smoking. No effect modification by sex or smoking status was identified. Findings were similar between the ECRHS and the SAPALDIA cohorts.Conclusions: Our results greatly strengthen the evidence base implicating occupation, independent of smoking, as a risk factor for lung-function decline. This highlights the need to prevent or control these exposures in the workplace. |
| Databáze: | OpenAIRE |
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