Systemic calprotectin and chronic inflammatory rheumatic diseases
| Autor: | Candice Trocme, Anaïs Courtier, Bertrand Toussaint, Minh Vu Chuong Nguyen, Philippe Gaudin, Xavier Romand, Margot Clapasson, Marie-Hélène Paclet, Chloé Bernardy, Athan Baillet |
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| Přispěvatelé: | Groupe de Recherche et d’Étude du Processus Inflammatoire (GREPI), Université Joseph Fourier - Grenoble 1 (UJF)-EFS, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]) |
| Rok vydání: | 2019 |
| Předmět: |
Male
Complete data [SDV]Life Sciences [q-bio] Arthritis Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Inflammation Risk Assessment Severity of Illness Index Inflammatory bowel disease Arthritis Rheumatoid 03 medical and health sciences fluids and secretions 0302 clinical medicine Rheumatology Rheumatic Diseases Humans Medicine Spondylitis Ankylosing 030304 developmental biology 030203 arthritis & rheumatology 0303 health sciences Ankylosing spondylitis Innate immune system business.industry medicine.disease Arthritis Juvenile 3. Good health Rheumatoid arthritis Chronic Disease Immunology Disease Progression Female medicine.symptom Calprotectin business Leukocyte L1 Antigen Complex Biomarkers Follow-Up Studies |
| Zdroj: | Joint Bone Spine Joint Bone Spine, Elsevier Masson, 2019, 86, pp.691-698. ⟨10.1016/j.jbspin.2019.01.003⟩ |
| ISSN: | 1297-319X |
| Popis: | Calprotectin is a calcium binding protein produced by neutrophils and monocytes locally at the site of inflammation in order to trigger the innate immunity receptors. This unique characteristic makes it a good proxy for evaluation of local inflammation in chronic inflammatory rheumatic diseases. Complete data suggest, in inflammatory rheumatic diseases, a relevant role of calprotectin in the inflammatory process. The interest of serum or plasma calprotectin dosage has been studied intensively, in the current years, especially in rheumatoid arthritis, spondyloarthritis, juvenile idiopathic arthritis and ANCA associated vasculitis. Calprotectin seems to be a great candidate as biomarker to assess and monitor disease activity, to predict structural progression or response to the treatment. Calprotectin showed its ability to predict radiological progression in rheumatoid arthritis and ankylosing spondylitis. Serum calprotectin can predict the risk of relapse in ANCA associated vasculitis and the risk of inflammatory bowel disease in spondyloarthritis. Nevertheless, studies report controversial result requiring replication in other large cohort. The lack of assay standardization between studies is a problem to replicate and compare studies. In this review, we discuss on the interest of systemic calprotectin in chronic inflammatory rheumatic disease as a diagnostic, activity or prognostic biomarker. |
| Databáze: | OpenAIRE |
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