Fatigue is associated with high circulating leptin levels in chronic hepatitis C
| Autor: | M L Montoya, Sylvia Benzaken, Xavier Hébuterne, Patrick Hastier, Thierry Piche, Jean Giudicelli, E. Gelsi, C. Laffont, B. Ferrua, Albert Tran, Patrick Rampal, Stéphane M. Schneider, F. Longo |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Letter Gastroenterology Severity of Illness Index Primary biliary cirrhosis Internal medicine Surveys and Questionnaires medicine Humans Resting energy expenditure Prospective Studies Fatigue biology medicine.diagnostic_test business.industry Liver Cirrhosis Biliary Tumor Necrosis Factor-alpha Liver Disease Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Endocrinology Alanine transaminase Liver biopsy biology.protein Body Composition Female business Liver function tests Viral load |
| Zdroj: | Gut. 51(3) |
| ISSN: | 0017-5749 |
| Popis: | Background and aims: Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC). Its mechanism is poorly understood. Recent attention has focused on the role of leptin and energy expenditure in CHC. Our aims were to analyse fatigue in CHC and to determine its relationship with disease activity, resting energy expenditure (REE), circulating leptin, and tumour necrosis factor α (TNF-α). Methods: Seventy eight CHC patients, 22 healthy controls, and 13 primary biliary cirrhosis (PBC) patients underwent measurements of REE, body composition, leptin, and TNF-α. All subjects completed the fatigue impact scale (FIS) questionnaire. A liver biopsy and viral load measurements were performed in all patients. Results: Thirty eight of 78 CHC patients considered fatigue the worst or initial symptom of their disease. The fatigue score of patients was significantly higher than that of controls (53.2 (40.1) v 17.7 (16.9); p |
| Databáze: | OpenAIRE |
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