The sources of calcium for noradrenaline-induced contraction in the human thoracic internal artery
| Autor: | Anna Kostrzewska, Beata Modzelewska, Leszek Buzun, Ewa Kleszczewska, Tomasz Kleszczewski |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Thapsigargin Contraction (grammar) Physiology Clinical Biochemistry chemistry.chemical_element Internal thoracic artery 030204 cardiovascular system & hematology Calcium Potassium Chloride Norepinephrine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physiology (medical) Internal medicine medicine.artery medicine Extracellular Humans Vasoconstrictor Agents Mammary Arteries Aged Aged 80 and over Middle Aged Extracellular Matrix Endocrinology medicine.anatomical_structure chemistry Vasoconstriction 030220 oncology & carcinogenesis Anesthesia Female Endothelium Vascular medicine.symptom Muscle Contraction Muscle contraction Artery |
| Zdroj: | Pflügers Archiv - European Journal of Physiology. 469:1135-1140 |
| ISSN: | 1432-2013 0031-6768 |
| Popis: | The aim of the present study was to examine the contribution of intracellular and extracellular calcium sources in contraction caused by noradrenaline (NA) of the human internal thoracic artery (ITA) in vitro. Distal segments of ITA were obtained from 20 patients (aged 38–73, at the time of routine coronary artery surgical revascularization (CABG)). Contractile responses to 10−6 mol/L NA in the physiological salt solution and in Ca2+-free solution without and after incubation with 10−6 mol/L thapsigargin (TSG) were recorded under isometric conditions. Responses of ITA rings to 1 μM NA without incubation with TSG accounted (% of reaction to 80 mM KCl) 224.70 ± 14.06% in PSS solution, 141.30 ± 8.66% in Ca2+-free solution, and 80.03 ± 1.71% after PSS restoration and were statistically significantly different (p |
| Databáze: | OpenAIRE |
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