For early-stage oral tongue cancer, depth of invasion and worst pattern of invasion are the strongest pathological predictors for locoregional recurrence and mortality
| Autor: | Luiz Paulo Kowalski, Natalie Kelner, Jaana Hagström, Veli-Matti Kosma, Antti Mäkitie, Jussi Laranne, Matti Pukkila, Ricardo D. Coletta, Tuula Salo, Petri Koivunen, Ibrahim O. Bello, Laura K. Mäkinen, Ilmo Leivo, Alhadi Almangush, Esa Läärä, Ylermi Soini, Joonas H. Kauppila, Reidar Grénman |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Adolescent medicine.medical_treatment Perineural invasion Pathology and Forensic Medicine Tongue Internal medicine medicine Carcinoma Humans Neoplasm Invasiveness Stage (cooking) Child Molecular Biology Aged Neoplasm Staging Proportional Hazards Models Aged 80 and over Squamous Cell Carcinoma of Head and Neck Proportional hazards model business.industry Hazard ratio Neck dissection Cell Biology General Medicine Middle Aged medicine.disease Tongue Neoplasms Surgery medicine.anatomical_structure Head and Neck Neoplasms Carcinoma Squamous Cell Glossectomy Female Neoplasm Recurrence Local business |
| Zdroj: | Virchows Archiv. 467:39-46 |
| ISSN: | 1432-2307 0945-6317 |
| DOI: | 10.1007/s00428-015-1758-z |
| Popis: | Despite early diagnosis and treatment, almost 20 % of patients with early-stage (cT1-cT2N0) oral tongue squamous cell carcinoma (OTSCC) still die of their disease. The prognosis of OTSCC patients is influenced by several demographic, clinical, and histopathologic factors. The aim of this multicenter international study was to find which of the factors age, gender, stage, grade, lymphocytic host re- sponse, perineural invasion, worst pattern of invasion, or depth of invasion has the strongest prognostic power in early-stage OTSCC. Patient data of 479 patients with early-stage (cT1-2N0) OTSCC in Finland, Brazil, and the USA were retrieved and analyzed using Cox proportional hazards regression models. Our results indicate that depth of invasion (DOI) and worst pattern of invasion (WPOI) are the strongest pathological predictors for locoregional recurrence, with a hazard ratio (HR) for 4 mm DOI of 1.67 (95 % confidence interval (CI) 1.07-2.60) and HR for WPOI of 1.46 (95 %C I 0.95-2.25). In addition, mor- tality from early OTSCC was also predicted by DOI (HR 2.44, 95 % CI 1.34-4.47) and by WPOI (HR 2.34, 95 % CI 1.26-4.32). We suggest that clinically early-stage oral tongue carcinomas 4 mm or deeper, or with a growth pat- tern of small cell islands or satellites, should be considered as high-risk tumors which require multimodality treatment. |
| Databáze: | OpenAIRE |
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