Cortical motor threshold determination in dogs
| Autor: | Lise Vlerick, L. Van Ham, Ingeborgh Polis, N. Van Laeken, F. De Vos, Kathelijne Peremans, Sofie Bhatti, Robrecht Dockx, Chris Baeken, Jimmy Saunders |
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| Přispěvatelé: | Brain, Body and Cognition, Clinical sciences, Neuroprotection & Neuromodulation, Psychiatry, Faculty of Medicine and Pharmacy |
| Rok vydání: | 2019 |
| Předmět: |
Male
Coil-cortex distance electromyography congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Under sedation 040301 veterinary sciences medicine.medical_treatment Electromyography Audiology Anaesthesia 0403 veterinary science Age and gender 03 medical and health sciences Dogs Sex Factors Animal model DOG Animals Medicine 030304 developmental biology Motor threshold 0303 health sciences Cortical motor threshold General Veterinary medicine.diagnostic_test business.industry Motor Cortex 04 agricultural and veterinary sciences Repeatability Evoked Potentials Motor Transcranial Magnetic Stimulation veterinary(all) nervous system diseases Transcranial magnetic stimulation Female Deep Sedation business Canine model |
| Zdroj: | Research in Veterinary Science. 124:248-255 |
| ISSN: | 0034-5288 |
| DOI: | 10.1016/j.rvsc.2019.03.022 |
| Popis: | In humans, determining the cortical motor threshold (CMT) is a critical step in successfully applying a transcranial magnetic stimulation (TMS) treatment. Stimulus intensity, safety and efficacy of a TMS treatment are dependent of the correct assessment of the CMT. Given that TMS in dogs could serve as a natural animal model, an accurate and reliable technique for the measurement of the CMT should be available for dogs. Using a visual descending staircase paradigm (Rossini paradigm), the CMT repeatability was assessed and compared to the electromyographic (EMG) variant. The influence of a HF-rTMS treatment on the CMT was examined. Subsequently, the CMT was measured under sedation and general anaesthesia. Finally, the coil-cortex distance was associated with the CMT, weight, age and gender. During one year the CMT was measured three times, during which it remained constant, although a higher CMT was measured (40% higher machine output) when using EMG (P-value |
| Databáze: | OpenAIRE |
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