CAUSES AND CONSEQUENCES OF IRON DEFICIENCY WITHOUT ANEMIA IN THE PRACTICE OF GYNECOLOGIST
| Autor: | N. V. Kosei, T. F. Tatarchuk, N. F. Zakharenko, K. S. Pavlova |
|---|---|
| Jazyk: | ukrajinština |
| Rok vydání: | 2020 |
| Předmět: |
Anemia
Endocrinology Diabetes and Metabolism Physiology 030209 endocrinology & metabolism iron bisglycinate 03 medical and health sciences 0302 clinical medicine iron deficiency medicine transferrin chemistry.chemical_classification 030219 obstetrics & reproductive medicine tolerance biology business.industry Transferrin saturation ferritin Obstetrics and Gynecology Gynecology and obstetrics Iron deficiency medicine.disease anemia Ferritin Reproductive Medicine chemistry Tolerability Iron-deficiency anemia Transferrin RG1-991 Etiology biology.protein abnormal uterine bleeding oral iron preparations business |
| Zdroj: | Репродуктивная эндокринология, Vol 0, Iss 56, Pp 13-17 (2020) |
| Popis: | The effect of iron deficiency (ID) without anemia on the reproductive health of women in contrast to iron deficiency anemia is still insufficiently evaluated from a clinical point of view, despite a weighty theoretical basis and a large pool of clinical observations. The purpose of this review is to systematize the ID causes without anemia in women associated and not associated with reproductive disorders, the effects of ID without anemia on reproductive health, and modern approaches to the diagnosis and treatment of this pathology. ID without anemia affects most of the physiological processes in a woman's body, including hormonal regulation, immune processes and functions of the nervous system. The negative effect of ID without anemia on a woman's reproductive function is realized through hormone-mediated and immune mechanisms. ID without anemia is currently underestimated in terms of somatic and reproductive health of women, as well as quality of life. Сlinical manifestations of ID without anemia are mostly nonspecific, which is why clinicians, focusing only on hematological parameters are often explaining them by other reasons, which leads to late diagnosis. Assessment of hematological parameters alone is accompanied by significant underdiagnosis of ID without anemia. Diagnosis of ID without anemia should be carried out in women with risk factors (abnormal uterine bleeding, heavy menstrual bleeding, etc.), as well as with dyshormonal disorders, recurrent inflammatory processes in combination with ID symptoms by assessing the ferritin and transferrin saturation. To treat ID without anemia it is necessary to eliminate the etiological factor and carry out a sufficiently long-term supplementation with oral iron preparations with good tolerance and bioavailability. Iron bisglycinate is the form of iron intake that does not affect the mucous membrane of the gastrointestinal tract and is absorbed by the small intestine mucosa unchanged, which ensures its good tolerability and high efficiency for the correction of ID. |
| Databáze: | OpenAIRE |
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