Exploring the Genetic Etiology of Trust in Adolescents: Combined Twin and DNA Analyses
| Autor: | Claire M. A. Haworth, Robyn E Wootton, Oliver S. P. Davis, Abigail L. Mottershaw, R. Adele H. Wang |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Genotype Restricted maximum likelihood Twins Friends Single-nucleotide polymorphism Genome-wide association study heritability Biology Social Environment Polymorphism Single Nucleotide Article DNA-Based Heritability Young Adult 03 medical and health sciences Missing heritability problem Genetic variation Humans Genetics (clinical) Genetics DNA-based heritability Genetic Variation Obstetrics and Gynecology Social environment trust Heritability United Kingdom Phenotype 030104 developmental biology twin design Pediatrics Perinatology and Child Health Female Twins Early Development Study Genome-Wide Association Study Demography |
| Zdroj: | Wootton, R E, Davis, O S, Mottershaw, A L, Wang, A & Haworth, C M A 2016, ' Exploring the genetic aetiology of trust in adolescents : Combined twin and DNA analyses ', Twin Research and Human Genetics, vol. 19, no. 6, pp. 638-646 . https://doi.org/10.1017/thg.2016.84 Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISSN: | 1839-2628 1832-4274 |
| DOI: | 10.1017/thg.2016.84 |
| Popis: | Behavioral traits generally show moderate to strong genetic influence, with heritability estimates of around 50%. Some recent research has suggested that trust may be an exception because it is more strongly influenced by social interactions. In a sample of over 7,000 adolescent twins from the United Kingdom's Twins Early Development Study, we found broad sense heritability estimates of 57% for generalized trust and 51% for trust in friends. Genomic-relatedness-matrix restricted maximum likelihood (GREML) estimates in the same sample indicate that 21% of the narrow sense genetic variance can be explained by common single nucleotide polymorphisms for generalized trust and 43% for trust in friends. As expected, this implies a large amount of unexplained heritability, although power is low for estimating DNA-based heritability. The missing heritability may be accounted for by interactions between DNA and the social environment during development or via gene–environment correlations with rare variants. How these genes and environments correlate seem especially important for the development of trust. |
| Databáze: | OpenAIRE |
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