Numerical modeling of nanoparticle deposition in realistic monkey airway and human airway models: a comparative study
| Autor: | Nguyen Lu Phuong, Nguyen Dang Khoa, Kazuhide Ito |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Cfd simulation Materials science Health Toxicology and Mutagenesis Respiratory System Numerical modeling Inhalation Toxicology 010501 environmental sciences Toxicology Models Biological 01 natural sciences 03 medical and health sciences 0302 clinical medicine Administration Inhalation Animals Humans Computer Simulation Particle Size Nanoparticle deposition 0105 earth and related environmental sciences Inhalation Exposure Haplorhini Human airway 030228 respiratory system Hydrodynamics Nanoparticles Airway Biomedical engineering |
| Zdroj: | Inhalation Toxicology. 32:311-325 |
| ISSN: | 1091-7691 0895-8378 |
| Popis: | One of the most promising approaches to understand inhalation toxicology and to assess the potential risks of inhaled particles is to examine the disposition of the hazardous airborne particles in the monkey airway. This study presents a comparative, numerical investigation of nanoparticle deposition in the monkey and human airway models.Computational fluid dynamics (CFD) method was applied to analyze the steady flow rates under light and moderate metabolic conditions. The nanoparticles, ranging from 5 to 100 nm in diameter, were used to predict the total and regional deposition fraction in both the models.The Brownian and turbulent motion significantly impacted the transportation and deposition of nanoparticles as evidenced by the large fluctuations of particle acceleration. A higher deposition efficiency was observed in the monkey model at the particle size of 25 nm or less. Nonetheless, on applying the geometric factors for combined diffusion term parameters, the total deposition fraction of both models converged into a single curve. The site-specific deposition of the particles of size 5 nm in the vestibule, valve, and nasal turbinate regions of the monkey model was observed to be greater compared to the human model. A study of the deposition curves of the particle diameter ranging from 2 nm to 10 µm showed that the highest deposition rates were associated with particles of size 2 nm and 10 µm.The results of this study can contribute to the research involving extrapolation of inhalation toxicology studies, from monkeys to humans. |
| Databáze: | OpenAIRE |
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