Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks
| Autor: | Mariana Yaneva, Ulf Grawunder, Xiantuo Wu, Michael R. Lieber |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Saccharomyces cerevisiae Proteins
Mammalian Genetics Ku80 DNA Repair Ku Autoantigen DNA-Dependent Protein Kinase DNA-Activated Protein Kinase Protein Serine-Threonine Kinases Biology chemistry.chemical_compound Yeasts Genetics Animals Double strand DNA Helicases Nuclear Proteins Antigens Nuclear DNA repair protein XRCC4 Molecular biology Yeast Cell biology DNA-Binding Proteins chemistry DNA Developmental Biology |
| Zdroj: | Current Opinion in Genetics & Development. 7:99-104 |
| ISSN: | 0959-437X |
| DOI: | 10.1016/s0959-437x(97)80116-5 |
| Popis: | A convergence of information from biochemistry, yeast and mammalian genetics, immunology, and radiation biology has permitted identification of some of the protein participants - Ku, DNA-PK, XRCC4 - and the reaction intermediates in DNA end joining, suggesting how broken chromosomal ends may be recognized and repaired in eukaryotic cells. Some components may be defective in inherited disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect