Glycemic Variability Determined by Continuous Glucose Monitoring System Predicts Left Ventricular Remodeling in Patients With a First ST-Segment Elevation Myocardial Infarction
| Autor: | Masami Kosuge, Eiichi Akiyama, Kiyoshi Hibi, Shunsuke Kataoka, Kentaro Sakamaki, Kazuo Kimura, Masaomi Gohbara, Kengo Tsukahara, Toshiaki Ebina, Satoshi Umemura, Nobuhiko Maejima, Noriaki Iwahashi, Yoshikazu Hayakawa |
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| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Myocardial Infarction Cardiac magnetic resonance imaging Internal medicine medicine Humans ST segment Prospective Studies cardiovascular diseases Myocardial infarction Ventricular remodeling Prospective cohort study Aged Glycemic Ventricular Remodeling medicine.diagnostic_test business.industry General Medicine Odds ratio Middle Aged medicine.disease Magnetic Resonance Imaging Confidence interval Radiography Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation Journal. 79:1092-1099 |
| ISSN: | 1347-4820 1346-9843 |
| Popis: | BACKGROUND Impaired glucose metabolism plays an important role in patients with acute myocardial infarction, but the clinical significance of glycemic variability (GV) early after the onset of ST-segment elevation myocardial infarction (STEMI) remains to be fully elucidated. METHODS AND RESULTS We prospectively investigated the clinical impact of GV, as determined by a continuous glucose monitoring system (CGMS), on left ventricular remodeling (LVR) assessed by cardiac magnetic resonance imaging (CMR) in 69 patients (63±13 years, 59 men) with a first reperfused STEMI within 12 h of onset. All patients were equipped with a CGMS when in a stable phase after admission and underwent repeat CMR at baseline and 7 months follow-up. Patients were divided into 2 groups according to the mean amplitude of glycemic excursions (MAGE). Patients in the upper tertile of MAGE were categorized as group High (H) and the other two-thirds as group Low (L). LVR was defined as an absolute increase in left ventricular end-diastolic volume index of ≥20%. LVR more frequently occurred in group H than in group L (56% vs. 11%, P |
| Databáze: | OpenAIRE |
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