Coronary collateralization prevents myocardial ROS surge induced by revascularization after non–ST-elevation acute coronary syndrome: A pilot study
| Autor: | Jasna Marinovic, Marko Ljubkovic, Nadica Maltar-Strmecki, Jaksa Zanchi, Ivan Mihanovic, Cristijan Bulat |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Acute coronary syndrome Time Factors Public Health and Health Care medicine.medical_treatment Coronary Artery Bypass Off-Pump Collateral Circulation Myocardial Reperfusion Injury Pilot Projects 030204 cardiovascular system & hematology Coronary Angiography Revascularization Pathophysiology 03 medical and health sciences 0302 clinical medicine Risk Factors Coronary Circulation Internal medicine Humans Medicine Non-ST Elevated Myocardial Infarction Aged 030304 developmental biology 0303 health sciences business.industry Physics Myocardium ST elevation Electron Spin Resonance Spectroscopy Basic Medical Sciences Middle Aged medicine.disease 3. Good health Chemistry Oxidative Stress Treatment Outcome Cardiology reperfusion injury mitochondria reactive oxygen species acute coronary syndrome Surgery Female Reactive Oxygen Species Cardiology and Cardiovascular Medicine business Collateralization |
| Zdroj: | Progress in Cardiovascular Diseases |
| Popis: | Revascularization therapies are essential for efficient treatment of acute coronary syndrome. Yet, besides rescuing the affected myocardium from excessive damage, reperfusion also inflicts additional injury. In this study, we assessed levels of reactive oxygen species (ROS), the main culprits of reperfusion injury, in myocardium of patients undergoing revascularization after acute coronary syndrome. We found that revascularization by coronary artery bypass grafting after non-ST elevation acute coronary syndrome is associated with significant increase in ROS levels in patients without developed coronary artery collaterals, but patients with collateralization exhibit no such effect of reperfusion. This demonstrates protective effect of coronary artery collateralization and re-iterates the vulnerability of patients without collaterals, making them most appropriate candidates for cardioprotective interventions targeting the reperfusion injury. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|