PSYCHOMOTOR PERFORMANCE DURING INITIAL STAGE OF EXPOSURE TO HALOTHANE, ENFLURANE, ISOFLURANE AND SEVOFLURANE IN MICE
| Autor: | Masaaki Ueki, Norihumi Kuratani, Junko Nogaya, Kenji Ogli, Satoshi Yokono, Hisao Komatsu |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Male
Methyl Ethers Reinforcement Schedule Physiology Poison control Mice Inbred Strains Sevoflurane Enflurane Mice Physiology (medical) medicine Animals Pharmacology Psychomotor learning Isoflurane Inhalation business.industry Biphasic Pattern Anesthesia Anesthetics Inhalation Conditioning Operant Halothane business Psychomotor Performance Ethers medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 24:706-709 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1997.tb02116.x |
| Popis: | 1. The dose-response relationship during the pre-anaesthetic and pre-equilibrium state of four inhalation anaesthetics (halothane, enflurane, isoflurane and sevoflurane) on fixed-ratio schedule-controlled behaviour was studied in mice. 2. Animals exposed to halothane, enflurane and isoflurane showed a biphasic pattern (i.e. a significant incremental increase in psychomotor responses at low inspired concentrations (0.1-0.4%) and decrements at greater concentrations) in a dose-dependent manner. Mean peak responses (per cent of control) were 132.3 (P < 0.01 vs control), 124.0 (P < 0.05) and 116.7% (P < 0.05) at 0.1% halothane, 0.3% enflurane and 0.2% isoflurane, respectively. 3. Sevoflurane did not increase schedule-controlled behavioural responses at any concentration. 4. The effect of subanaesthetic concentrations of inhalation anaesthetics on psychomotor performance can be evaluated as changes in the response rate in schedule-controlled behaviour. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text