Primary adenoid cystic carcinoma of the tracheobronchial tree: A decade-long experience at a health centre in Mexico
| Autor: | Daniel Mendoza-Posada, Arturo Cortés-Télles |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pulmonary and Respiratory Medicine
lcsh:RC705-779 medicine.medical_specialty Adenoid cystic carcinoma business.industry respiratory function tests prevalence Fatal outcomes Disease lcsh:Diseases of the respiratory system medicine.disease Health centre Surgery FEV1/FVC ratio Internal medicine medicine Arterial blood Original Article Respiratory system business Lung cancer Pathological primary adenoid cystic carcinoma tracheobronchial neoplasms |
| Zdroj: | Lung India : Official Organ of Indian Chest Society Lung India, Vol 29, Iss 4, Pp 325-328 (2012) |
| ISSN: | 0970-2113 |
| Popis: | Background : Mexico's National Institute of Respiratory Diseases (NIRD) is a third-level national reference center. Primary adenoid cystic carcinoma (PACC) is an uncommon neoplastic disorder; hence improvements in the description of this disease are needed. Materials and Methods: This is a retrospective clinical study based on all consecutive patients with pathological diagnoses of PACC seen at the NIRD between January 1, 2000 and December 31, 2009. Results: We identified 9 cases of PACC (67% female) out of a total of 2,634 patients with lung cancer seen during the period analyzed. The mean age of those 9 patients was 41 years (IQR 36-57), and the frequency of PACC at our center was 0.3%. It is important to note that 67% of those patients had a history of smoking and that 6 of the 9 had the antecedent of previous exposure to biomass fuel smoke. Baseline arterial blood gas analyses revealed a median of 61 mmHg for pO 2 and 28.5 mmHg for pCO 2 . Median FVC was 78%, while FEV 1 was 77% with an FEV 1 /FVC ratio of 78. Death occurred in 56% of cases, and the median survival time was 17 months (IQR 6-26) after the initial diagnosis. Conclusions: The frequency of tracheobronchial PACC among patients with lung cancer was similar to that previously reported (0.3%). According to our results, lung function has no specific phenotype in this disease; however, some abnormalities could be related to potential risk factors such as tobacco use and exposure to biomass fuel smoke. |
| Databáze: | OpenAIRE |
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