Proton magnetic resonance spectroscopy in youth with severe mood dysregulation
| Autor: | Daniel P. Dickstein, Kenneth E. Towbin, Ellen Leibenluft, Lisa Knopf, Daniel S. Pine, Jan Willem van der Veen |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Nosology medicine.medical_specialty Bipolar Disorder Magnetic Resonance Spectroscopy Phosphocreatine Lithium (medication) Glutamine Neuroscience (miscellaneous) Irritability Brain mapping Diagnosis Differential Double-Blind Method Antimanic Agents Internal medicine Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging Bipolar disorder Irritable Mood Dominance Cerebral Cerebral Cortex Aspartic Acid Brain Mapping Mood Disorders Glutamate receptor Creatine medicine.disease Psychiatry and Mental health Mood Attention Deficit Disorder with Hyperactivity Chronic Disease Lithium Compounds medicine.symptom Arousal Psychology Inositol medicine.drug Clinical psychology |
| Zdroj: | Psychiatry Research: Neuroimaging. 163:30-39 |
| ISSN: | 0925-4927 |
| DOI: | 10.1016/j.pscychresns.2007.11.006 |
| Popis: | Increasing numbers of youth are presenting for psychiatric evaluation with markedly irritable mood plus "hyperarousal" symptoms. Diagnostically homeless in current nosology, the syndrome (as well as its underlying neurobiology) is little understood. To address this problem, we conducted an exploratory proton magnetic resonance spectroscopy (MRS) study in a large sample of youth with chronic, functionally disabling irritability accompanied by hyperarousal, a clinical syndrome known as "severe mood dysregulation" (SMD), which may represent a broad phenotype of pediatric bipolar disorder. Medication-free SMD youth (N=36) and controls (N=48) underwent 1.5 Tesla MRS in four regions of interest. The following three neurometabolites, relative to creatine (Cr), were quantified with LCModel Software: (a) myo-inositol (mI), a marker of intra-cellular second messengers linked to the neurobiology of bipolar disorder; (b) glutamate/glutamine (GLX), a marker of the major excitatory neurotransmitter glutamate; and (c) N-acetyl aspartate (NAA), a marker of neuronal energetics. SMD subjects had significantly lower temporal mI/Cr versus controls. However, this difference did not survive correction for multiple comparisons. Given studies implicating mI in lithium's action in BD adults and youth, further work is necessary to determine potential therapeutic implications of our present finding and how SMD youth differ pathophysiologically from those with strictly defined BD. |
| Databáze: | OpenAIRE |
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