Several Lipid-Related Gene Polymorphisms Interact with Overweight/Obesity to Modulate Blood Pressure Levels
| Autor: | Lin Zhang, Wan-Ying Liu, Ting-Ting Yan, Xiao-Li Cao, Lin Miao, Rui-Xing Yin, Xing-Jiang Long, Lynn Htet Htet Aung, Dong-Feng Wu, Meng Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Endothelial lipase
Adult Male medicine.medical_specialty obesity China hypertension Adolescent Genotype interaction MYLIP Biology Overweight Polymorphism Single Nucleotide Catalysis Article lcsh:Chemistry Inorganic Chemistry Internal medicine medicine genetic polymorphism overweight Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy PCSK9 Organic Chemistry blood pressure Epistasis Genetic General Medicine Middle Aged medicine.disease Lipid Metabolism Obesity SCARB1 Computer Science Applications Endocrinology lcsh:Biology (General) lcsh:QD1-999 Methylenetetrahydrofolate reductase biology.protein Female Hepatic lipase medicine.symptom |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences; Volume 13; Issue 9; Pages: 12062-12081 International Journal of Molecular Sciences, Vol 13, Iss 9, Pp 12062-12081 (2012) |
| ISSN: | 1422-0067 |
| Popis: | Little is known about the interactions of single nucleotide polymorphisms (SNPs) and overweight/obesity on blood pressure levels. The present study was undertaken to detect 10 lipid-related gene SNPs and their interactions with overweight/obesity on blood pressure levels. Genotyping of ATP-binding cassette transporter A1 (ABCA-1) V825I, acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) rs1044925, low density lipoprotein receptor (LDL-R) AvaII hepatic lipase gene (LIPC) −250G > A, endothelial lipase gene (LIPG) 584C > T, methylenetetrahydrofolate reductase (MTHFR) 677C > T, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein (MYLIP) rs3757354, proprotein convertase subtilisin-like kexin type 9 (PCSK9) E670G, peroxisome proliferator-activated receptor delta (PPARD) +294T > C, and Scavenger receptor class B type 1 (SCARB1) rs5888 was performed in 978 normal weight and 751 overweight/obese subjects. The interactions were detected by factorial regression analysis. The genotypes of ACAT-1 AC, LIPC GA and AA, and SCARB1 TT; LDL-R A-A- and LIPC GA; and SCARB1 TT were interacted with overweight/obesity to increase systolic, diastolic blood pressure (SBP, DBP) and pulse pressure (PP) levels; respectively. The genotypes of ACAT-1 CC; ACAT-1 AA and CC were interacted with overweight/obesity to decrease SBP, PP levels (p < 0.01–0.001); respectively. The differences in blood pressure levels between normal weight and overweight/obese subjects might partly result from different interactions of several SNPs and overweight/obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|