Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II
| Autor: | Michael Dettling, Florian Holsboer, Jürgen Schmider, Isabella Heuser, Diego Garcia-Borreguero, Ulrike Gotthardt, C.-H. Lammers |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Hypothalamo-Hypophyseal System endocrine system medicine.medical_specialty Psychosis Hydrocortisone Corticotropin-Releasing Hormone Pituitary-Adrenal System Stimulation Adrenocorticotropic hormone Dexamethasone Corticotropin-releasing hormone Adrenocorticotropic Hormone Reference Values Internal medicine Severity of illness medicine Humans Biological Psychiatry Psychiatric Status Rating Scales Middle Aged medicine.disease Treatment Outcome Endocrinology Schizophrenia Female Schizophrenic Psychology Psychology hormones hormone substitutes and hormone antagonists Antipsychotic Agents medicine.drug |
| Zdroj: | Biological Psychiatry. 38:803-807 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/0006-3223(95)00065-8 |
| Popis: | Hypothalamic-pituitary-adrenal system (HPA) function was tested in 24 patients with schizophrenia and compared to 24 age-matched healthy volunteers using the combined dexamethasone-suppression (DST/CRH) corticotropin-releasing hormone stimulation test (DST/CRH). After stimulation with CRH, the dexamethasone-pretreated patients released significantly more cortisol, but a similar amount of adrenocorticotropic hormone (ACTH) in comparison to controls. No association between DST status and degree of severity of illness and/or current medication was found. However, in comparison to unmedicated patients, those patients currently receiving antipsychotics, who were also those with a lesser degree of severity of illness, showed a decreased release of CRH-stimulated cortisol and ACTH. This study demonstrates that schizophrenic patients have a dysregulation of the HPA system as assessed with the DEX/CRH test. Overall, however, the degree of HPA-system dysfunction in schizophrenic patients seems to be of a lesser magnitude than in patients with affective disorders. |
| Databáze: | OpenAIRE |
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