Contribution of ultrasonographic examination to the prenatal detection of trisomy 21: experience from 19 European registers
| Autor: | Pa Boyd, Neus Baena, Diana Wellesley, Claude Stoll, C. De Vigan, Maurizio Clementi, E. Cariati |
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| Rok vydání: | 2004 |
| Předmět: |
Down syndrome
medicine.medical_specialty Aneuploidy Gestational Age Prenatal diagnosis Biology Ultrasonography Prenatal Pregnancy Genetics medicine Humans Mass Screening Registries medicine.diagnostic_test business.industry Obstetrics Ultrasound Pregnancy Outcome medicine.disease Europe Amniocentesis Gestation Female Down Syndrome business Trisomy Maternal Age |
| Zdroj: | Annales de Génétique. 47:373-380 |
| ISSN: | 0003-3995 |
| DOI: | 10.1016/j.anngen.2004.09.005 |
| Popis: | The objective of this study was to evaluate the contribution of ultrasound scanning to the prenatal detection of trisomy 21 in a large unselected European population. Data from 19 congenital malformation registers in 11 European countries were included. The prenatal ultrasound screening programs in the countries ranged from no routine screening to three ultrasound investigations per patient. Routine serum screening was offered in four of the 11 countries and routine screening on the basis of maternal age amniocentesis in all. The results show that overall 53% of cases of trisomy 21 were detected prenatally with a range from 3% in Lithuania to 88% in Paris. Ninety-eight percent of women whose babies were diagnosed before 24 weeks gestation chose to terminate the pregnancy. Centres/countries that offer serum screening do not have a significantly higher detection rate of trisomy 21 when compared to those that offer maternal age amniocentesis and anomaly scanning only. Fifty percent of trisomy 21 cases were born to women aged 35 years or more. In conclusions, second trimester ultrasound plays an important role in the prenatal diagnosis of trisomy 21. Of those cases prenatally diagnosed, 64% of cases in women |
| Databáze: | OpenAIRE |
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