Polyphenolic Compounds from Lespedeza Bicolor Root Bark Inhibit Progression of Human Prostate Cancer Cells via Induction of Apoptosis and Cell Cycle Arrest
| Autor: | Gunhild von Amsberg, Moritz Kaune, Sergey A. Fedoreyev, Markus Graefen, Carsten Bokemeyer, Anatoliy I. Kalinovskiy, M. V. Veselova, Tobias Busenbender, Sergey A. Dyshlovoy, Petr G. Gorovoy, Darya V. Tarbeeva, V. P. Grigorchuk, Jessica Hauschild, Natalya Kim |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Cell cycle checkpoint lcsh:QR1-502 Lespedeza Plant Roots Biochemistry Article lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine Cyclin-dependent kinase Lespedeza bicolor Humans Molecular Biology 030304 developmental biology 0303 health sciences biology Kinase Chemistry Pterocarpan apoptosis Polyphenols Prostatic Neoplasms Cell Cycle Checkpoints Cell cycle biology.organism_classification prostate cancer Molecular biology Apoptosis 030220 oncology & carcinogenesis PC-3 Cells Cancer cell Plant Bark biology.protein cell cycle pterocarpans Polyphenolic compounds |
| Zdroj: | Biomolecules Volume 10 Issue 3 Biomolecules, Vol 10, Iss 3, p 451 (2020) |
| ISSN: | 2218-273X |
| DOI: | 10.3390/biom10030451 |
| Popis: | From a root bark of Lespedeza bicolor Turch we isolated two new (7 and 8) and six previously known compounds (1&ndash 6) belonging to the group of prenylated polyphenols. Their structures were elucidated using mass spectrometry, nuclear magnetic resonance and circular dichroism spectroscopy. These natural compounds selectively inhibited human drug-resistant prostate cancer in vitro. Prenylated pterocarpans 1&ndash 3 prevented the cell cycle progression of human cancer cells in S-phase. This was accompanied by a reduced expression of mRNA corresponding to several human cyclin-dependent kinases (CDKs). In contrast, compounds 4&ndash 8 induced a G1-phase cell cycle arrest without any pronounced effect on CDKs mRNA expression. Interestingly, a non-substituted hydroxy group at C-8 of ring D of the pterocarpan skeleton of compounds 1&ndash 3 seems to be important for the CDKs inhibitory activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |