Continuous subcutaneous insulin infusion in children and adolescents with diabetes mellitus: decreased HbA1c with low risk of hypoglycemia
| Autor: | N. Sulli, Blegina Shashaj |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male Insulin pump medicine.medical_specialty Adolescent Diabetic ketoacidosis Injections Subcutaneous Endocrinology Diabetes and Metabolism medicine.medical_treatment Hypoglycemia Gastroenterology Body Mass Index Insulin Infusion Systems Endocrinology Internal medicine Diabetes mellitus medicine Humans Hypoglycemic Agents Insulin Child Infusion Pumps Glycated Hemoglobin Type 1 diabetes business.industry medicine.disease Diabetes Mellitus Type 1 Treatment Outcome Child Preschool Metabolic control analysis Pediatrics Perinatology and Child Health Female business Body mass index Follow-Up Studies |
| Popis: | AIM To evaluate blood glucose and HbA1c levels, insulin dosage, hypoglycemia rate and body mass index (BMI) at baseline, and at 3 and 6 months after initiation of continuous subcutaneous insulin infusion (CSII) in children and youth with type 1 diabetes mellitus (DM). METHODS A 6-month trial of pump therapy was carried out in 40 patients with type 1 DM and one with cystic fibrosis (CF) induced DM (25 males), aged 4-25 years (mean 13.5 +/- 4.2 [SD]; 4-8 years, n = 6; 8-10 years, n = 8; 10-12 years, n = 4; 12-15 years, n = 11; >15 years, n = 12). RESULTS HbA1c was significantly reduced from 9.5 +/- 1.7% to 8.6 +/- 1.2% at 3 months (p < 0.03), and at 6 months 8.8 +/- 1.5% (p < 0.05). The mean daily values of blood glucose, as well as individual mean values of blood glucose at fasting and before lunch, also exhibited a significant reduction (p < 0.05) at 3 and 6 months. There was a significant reduction in the number of hypoglycemic events (level of plasma glucose |
| Databáze: | OpenAIRE |
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