Progesterone effects on vaginal cytokines in women with a history of preterm birth

Autor: Tatyana Peresleni, David Garry, Michael Demishev, David Baker, Christina Kocis, Malini D. Persad
Rok vydání: 2018
Předmět:
0301 basic medicine
Physiology
Maternal Health
Interleukin-1beta
Blood Pressure
Pathology and Laboratory Medicine
Biochemistry
Vascular Medicine
Labor and Delivery
0302 clinical medicine
Pregnancy
Interleukin-1alpha
Immune Physiology
17 alpha-Hydroxyprogesterone Caproate
Medicine and Health Sciences
Prospective Studies
Lipid Hormones
Prospective cohort study
Immune Response
Progesterone
Innate Immune System
030219 obstetrics & reproductive medicine
Multidisciplinary
Interleukin-13
Obstetrics
Gestational age
Obstetrics and Gynecology
Vagina
Hypertension
Medicine
Gestation
Premature Birth
Cytokines
Female
Cohort study
medicine.drug
Research Article
Adult
medicine.medical_specialty
Adolescent
Science
Birth weight
Immunology
Gestational Age
Preterm Birth
03 medical and health sciences
Signs and Symptoms
Diagnostic Medicine
Hypertensive Disorders in Pregnancy
medicine
Humans
Vaginitis
Inflammation
business.industry
Infant
Newborn
Biology and Life Sciences
Molecular Development
medicine.disease
Immunity
Innate
Hormones
Pregnancy Complications
Administration
Intravaginal
030104 developmental biology
Gene Expression Regulation
Immune System
Birth
Interleukin-2
Women's Health
Progestins
business
Hydroxyprogesterone caproate
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 13, Iss 12, p e0209346 (2018)
ISSN: 1932-6203
Popis: ObjectiveTo determine the effect of intramuscular progesterone on the vaginal immune response of pregnant women with a history of prior preterm birth.MethodsA prospective, cohort study of women at 11-16 weeks gestation, ≥18 years of age, and carrying a singleton pregnancy was conducted from June 2016 to August 2017 after IRB approval. Women in the progesterone arm had a history of preterm birth and received weekly intramuscular 17-hydroxyprogesterone caproate. Controls comprised of women with healthy, uncomplicated pregnancies. Excluded were women with vaginitis, diabetes mellitus, hypertension, or other chronic diseases affecting the immune response. A vaginal wash was performed at enrollment, at 26-28 weeks, and at 35-36 weeks gestation. Samples underwent semi-quantitative detection of human inflammatory markers. Immunofluorescence pixel density data was analyzed and a P value ResultsThere were 39 women included, 10 with a prior preterm birth and 29 controls. The baseline demographics and pregnancy outcomes for both groups were similar in age, parity, race, BMI, gestational age at delivery, mode of delivery, and birth weight. Enrollment cytokines in women with a prior preterm birth, including IL-1 alpha (39.2±25.1% versus 26.1±13.2%; P = 0.04), IL-1 beta (47.9±26.4% versus 24.9±17%; PConclusionThere is an increased cytokine presence in vaginal washings of women at risk for preterm birth which appears to be modified following the administration of 17- hydroxyprogesterone caproate to levels similar to healthy controls.
Databáze: OpenAIRE
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