A unique case of esophageal carcinosarcoma with histopathological diversities
| Autor: | Terumasa Sashikata, Motoki Hiroyoshi, Shohei Matsuo, Yoshiki Nakamura, Nobuyuki Kondo, Yoshitane Tsukamoto, Ken-ichi Tomiyama |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty medicine.diagnostic_test business.industry medicine.disease Dysphagia Glandular Differentiation Pathology and Forensic Medicine Endoscopy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure 030220 oncology & carcinogenesis Biopsy Carcinosarcoma medicine lcsh:Pathology Adenocarcinoma medicine.symptom Basaloid Squamous Cell Carcinoma business Lymph node lcsh:RB1-214 |
| Zdroj: | Human Pathology: Case Reports, Vol 15, Iss, Pp 1-6 (2019) |
| ISSN: | 2214-3300 |
| Popis: | We report a 57-year-old Japanese male with esophageal carcinosarcoma with histopathological diversities. The patient complained of dysphagia. Endoscopy of the upper gastrointestinal tract revealed a mass in the lower esophagus just above the esophagogastric junction. Pathological diagnosis of the biopsy was poorly differentiated squamous cell carcinoma/undifferentiated carcinoma. Preoperative chemotherapy was performed with poor response. Post-operative analyses revealed that the chest CT showed the appearance of mineralization after neoadjuvant chemotherapy. Surgery revealed a mass in the lower esophagus invading the esophagogastric junction from above. The mass was macroscopically polypoid with an infiltrative ulcer. The pathological diagnosis of the surgical specimen was carcinosarcoma of the lower esophagus, composed of sarcomatoid components (undifferentiated pleomorphic sarcoma-like, osteosarcomatous and chondrosarcomatous), invasive adenocarcinoma with ductal and glandular differentiation, several foci of non-invasive squamous cell carcinoma and invasive conventional and basaloid squamous cell carcinoma (ypT3N0M0, stage II). One year after the operation, the left hilar lymph node enlarged. A biopsy of the lymph node showed adenocarcinoma, consistent with metastatic esophageal cancer. Additional chemotherapy was given. Two years and four months after the operation, the patient died of multiple metastases, these included the brain. Keywords: Esophagogastric junction, Carcinosarcoma, Squamous cell carcinoma, Adenocarcinoma, Osteosarcoma, Chondrosarcoma, Undifferentiated pleomorphic sarcoma |
| Databáze: | OpenAIRE |
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