Polymorphism rs10483727 in theSIX1/SIX6Gene Locus Is a Risk Factor for Primary Open Angle Glaucoma in a Saudi Cohort
| Autor: | Taif A. Azad, Altaf A. Kondkar, Faisal A. Almobarak, Saleh A. Al-Obeidan, Khaled K. Abu-Amero, Hatem Kalantan, Nasser A. Alsabaani, Tahira Sultan |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Genotype genetic structures Open angle glaucoma Saudi Arabia Ethnic group Locus (genetics) Polymorphism Single Nucleotide Cohort Studies 03 medical and health sciences 0302 clinical medicine Gene Frequency Internal medicine Basic Helix-Loop-Helix Transcription Factors Humans Medicine Genetic Predisposition to Disease Alleles Intraocular Pressure Genetics (clinical) Aged Homeodomain Proteins business.industry General Medicine Middle Aged eye diseases 030104 developmental biology Case-Control Studies Cohort Trans-Activators 030221 ophthalmology & optometry Female sense organs business Glaucoma Open-Angle |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 22:74-78 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2017.0159 |
| Popis: | Variant rs10483727 in the SIX1/SIX6 locus has been significantly associated with primary open angle glaucoma (POAG) in multiple ethnic groups. We conducted a case-control study to investigate the association between this variant and POAG in a Saudi cohort.Polymorphism rs10483727 was genotyped by using a TaqManThe "C" allele frequency was 0.33 and 0.45 among POAG cases and controls, respectively (odds ratio [OR] = 0.58, 95% confidence interval [CI] = 0.38-0.89; p = 0.013), suggesting a protective effect; and the "T" allele was associated with increased susceptibility to POAG (OR = 1.7, 95% CI = 1.11-2.58; p = 0.013). Genotype distribution was also significantly associated with POAG (χThe "T" allele of the rs10483727 polymorphism is an independent significant risk factor for POAG in the Saudi population. |
| Databáze: | OpenAIRE |
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