Structure-activity relationship in two series of aminoalkyl substituted coumarin inhibitors of gyrase B

Autor:	Alain Bonnefoy, Pascale Mauvais, Laurent Schio, Claudine Dupuis-Hamelin, Patrick Laurin, Michael Klich, Didier Ferroud, Patrice Lassaigne, Branislav Musicki
Rok vydání:	1999
Předmět:	Stereochemistry Clinical Biochemistry Pharmaceutical Science Gram-Positive Bacteria Peptides Cyclic Biochemistry Chemical synthesis DNA gyrase Structure-Activity Relationship chemistry.chemical_compound Coumarins Drug Discovery Escherichia coli medicine Topoisomerase II Inhibitors Structure–activity relationship heterocyclic compounds Enzyme Inhibitors Molecular Biology Novobiocin Antibacterial agent chemistry.chemical_classification Molecular Structure DNA Superhelical Chemistry Organic Chemistry Coumarin Anti-Bacterial Agents DNA Gyrase Molecular Medicine Antibacterial activity Lactone medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 9:2875-2880
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(99)00492-8
Popis:	Two series of aminosubstituted coumarins were synthesised and evaluated in vitro as inhibitors of DNA gyrase and as potential antibacterials. Novel novobiocin-like coumarins, 4-(dialkylamino)-methylcoumarins and 4-((2-alkylamino)ethoxy)coumarins, were discovered as gyrase B inhibitors with promising antibacterial activity in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8317ecf0f78a79b58fec6c034c268203 https://doi.org/10.1016/s0960-894x(99)00492-8 Zobrazit plný text záznamu Full Text from ScienceDirect