Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells
| Autor: | Chan Li, Tao Li, Randall J. Mrsny, Xiang Hu, Yixin He, Liu Muyun, Ji-Fan Hu, Xiaoping Zeng, Zeng Guifang, Yunxia Tang, Xin Zhou, Xingen Jiang, Jia Liu, Fanwei Meng, Jingyi Gan |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cancer Research medicine.medical_treatment Immunology Apoptosis Radiation-Protective Agents Hematopoietic stem cell transplantation Mesenchymal Stem Cell Transplantation Umbilical cord Umbilical Cord Superoxide dismutase Mice Immunology and Allergy Medicine Animals Humans Genetics (clinical) Transplantation Mice Inbred BALB C biology business.industry Superoxide Dismutase Mesenchymal stem cell Hematopoietic Stem Cell Transplantation Acute Radiation Syndrome Mesenchymal Stem Cells Cell Biology Hematopoiesis Haematopoiesis medicine.anatomical_structure Oncology Cancer research biology.protein Stem cell business |
| Zdroj: | Cytotherapy. 17(4) |
| ISSN: | 1477-2566 |
| Popis: | Background aims Acute radiation syndrome (ARS) leads to pancytopenia and multi-organ failure. Transplantation of hematopoietic stem cells provides a curative option for radiation-induced aplasia, but this therapy is limited by donor availability. Methods We examined an alternative therapeutic approach to ARS with the use of human extracellular superoxide dismutase (ECSOD)-modified umbilical cord mesenchymal stromal cells (UCMSCs). This treatment combines the unique regenerative role of UCMSCs with the anti-oxidative activity of ECSOD. Results We demonstrated that systemically administered ECSOD-UCMSCs are able to protect mice from sub-lethal doses of radiation and improve survival by promoting multilineage hematopoietic recovery. The therapeutic effect of this treatment is related to the decrease in radiation-induced O 2 – and apoptosis. Conclusions Our data highlight the clinical potential of this two-pronged approach to the treatment of ARS, thereby serving as a rapid and effective first-line strategy to combat the hematopoietic failure resulting from a radiation accident, nuclear terrorism and other radiologic emergencies. |
| Databáze: | OpenAIRE |
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