MexEF-OprN Efflux Pump Exports the Pseudomonas Quinolone Signal (PQS) Precursor HHQ (4-hydroxy-2-heptylquinoline)
| Autor: | Eric Déziel, Martin G. Lamarche |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Bacterial Diseases
Cystic Fibrosis Virulence Swarming motility lcsh:Medicine Biology Quinolones medicine.disease_cause Microbiology Virulence factor 03 medical and health sciences Antibiotic resistance Autosomal Recessive medicine Genetics Pseudomonas Infections Bacterial Physiology lcsh:Science 030304 developmental biology Clinical Genetics 0303 health sciences Multidisciplinary 030306 microbiology Pseudomonas aeruginosa lcsh:R Quorum Sensing Human Genetics Bacteriology Biological Transport Gene Expression Regulation Bacterial Molecular Development Signaling 3. Good health Bacterial Pathogens Quorum sensing Infectious Diseases Mutation Hydroxyquinolines Medicine Autoinducer lcsh:Q Efflux Research Article Developmental Biology Bacterial Outer Membrane Proteins |
| Zdroj: | PLoS ONE PLoS ONE, Vol 6, Iss 9, p e24310 (2011) |
| ISSN: | 1932-6203 |
| Popis: | Bacterial cells have evolved the capacity to communicate between each other via small diffusible chemical signals termed autoinducers. Pseudomonas aeruginosa is an opportunistic pathogen involved, among others, in cystic fibrosis complications. Virulence of P. aeruginosa relies on its ability to produce a number of autoinducers, including 4-hydroxy-2-alkylquinolines (HAQ). In a cell density-dependent manner, accumulated signals induce the expression of multiple targets, especially virulence factors. This phenomenon, called quorum sensing, promotes bacterial capacity to cause disease. Furthermore, P. aeruginosa possesses many multidrug efflux pumps conferring adaptive resistance to antibiotics. Activity of some of these efflux pumps also influences quorum sensing. The present study demonstrates that the MexEF-OprN efflux pump modulates quorum sensing through secretion of a signalling molecule belonging to the HAQ family. Moreover, activation of MexEF-OprN reduces virulence factor expression and swarming motility. Since MexEF-OprN can be activated in infected hosts even in the absence of antibiotic selective pressure, it could promote establishment of chronic infections in the lungs of people suffering from cystic fibrosis, thus diminishing the immune response to virulence factors. Therapeutic drugs that affect multidrug efflux pumps and HAQ-mediated quorum sensing would be valuable tools to shut down bacterial virulence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|