Multivalent manganese complex decorated amphiphilic dextran micelles as sensitive MRI probes

Autor:	Zhuzhong Cheng, Bin Song, Danyang Li, Ye Xu, Hou-Bing Zhang, Li Yang, Hua Ai, Chunchao Xia, Changqiang Wu, Bingbing Lin, Qiyong Gong
Rok vydání:	2020
Předmět:	Inorganic chemistry Biomedical Engineering chemistry.chemical_element General Chemistry General Medicine Manganese Conjugated system Micelle chemistry.chemical_compound Dextran chemistry In vivo Amphiphile Click chemistry General Materials Science Nuclear chemistry
Zdroj:	Journal of materials chemistry. B. 3(8)
ISSN:	2050-7518
Popis:	T 1 contrast agents based on Mn(II) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T1 relaxivity (13.3 Mn mmol−1 s−1) and better sensitivity than those of free Mn(II) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg−1 BW).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83164f6d781dcac97973bb94755419db https://pubmed.ncbi.nlm.nih.gov/32429604 Zobrazit plný text záznamu