Autor: |
Zhuzhong Cheng, Bin Song, Danyang Li, Ye Xu, Hou-Bing Zhang, Li Yang, Hua Ai, Chunchao Xia, Changqiang Wu, Bingbing Lin, Qiyong Gong |
Rok vydání: |
2020 |
Předmět: |
|
Zdroj: |
Journal of materials chemistry. B. 3(8) |
ISSN: |
2050-7518 |
Popis: |
T 1 contrast agents based on Mn(II) were conjugated on amphiphilic dextran micelles via click chemistry. The obtained paramagnetic nanomicelle contrast agent has a higher T1 relaxivity (13.3 Mn mmol−1 s−1) and better sensitivity than those of free Mn(II) complexes. Studies carried out in vivo suggest that this contrast agent has a better and long-acting vascular enhancement effect at a lower manganese dosage (0.1 Mn mmol kg−1 BW). |
Databáze: |
OpenAIRE |
Externí odkaz: |
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