IL1A rs1800587 associates with chronic noncrisis pain in sickle cell disease
| Autor: | Ying He, Robert E. Molokie, Yingwei Yao, Zaijie Jim Wang, Diana J. Wilkie, Ellie H. Jhun, Xiaoyu Hu |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Schmidt sting pain index Adolescent Anemia Sickle Cell Disease Polymorphism Single Nucleotide Pathogenesis Necrosis 03 medical and health sciences 0302 clinical medicine Pain assessment Interleukin-1alpha Internal medicine Genetics medicine Humans SNP Aged Genetic association Pharmacology business.industry Chronic pain Middle Aged medicine.disease 030104 developmental biology IL1A Molecular Medicine Female Chronic Pain business 030217 neurology & neurosurgery Research Article |
| Zdroj: | Pharmacogenomics. 17:1999-2006 |
| ISSN: | 1744-8042 1462-2416 |
| DOI: | 10.2217/pgs-2016-0085 |
| Popis: | Aim: Pain is prevalent in sickle cell disease (SCD) patients who display great heterogeneity in pain severity and frequency. Hypothesizing that inflammatory factors are involved in the pathogenesis of SCD pain, we focused on the IL1A C/T polymorphism rs1800587 that is an SNP located in a cis-transcriptional regulatory region. Methods: We genotyped IL1A rs1800587 and performed association studies with phenotype data obtained by a multidimensional pain assessment tool using the PAINReportIt® Questionnaire. Results: Each T allele was associated with a 3.9 increase in composite pain index score (p = 0.04) as determined by multiple linear regression. Conclusion: IL1A rs1800587 may influence chronic pain in SCD. |
| Databáze: | OpenAIRE |
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