Altered pulsatile pattern of luteinizing hormone in men with idiopathic normogonadotropic oligospermia
| Autor: | Anabel Romo, Emilio Del Pozo, Ester Polak, Abraham Guitelman, Oscar Levalle, Gustavo Aszenmil, Beatriz Espínola |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
Male endocrine system medicine.medical_specialty medicine.drug_class Pulsatile flow Chorionic Gonadotropin Clomiphene Internal medicine Humans Medicine Testosterone In patient Secretion Estradiol business.industry Obstetrics and Gynecology Oligospermia Luteinizing Hormone Lh pulsatility medicine.disease Endocrinology Reproductive Medicine Follicle Stimulating Hormone Gonadotropin business Luteinizing hormone Pituitary Hormone-Releasing Hormones hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Fertility and Sterility. 50:337-342 |
| ISSN: | 0015-0282 |
| Popis: | Gonadotropin serum levels and pulsatile secretion of gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) are regulated by sexual steroids and perhaps inhibin, but the relative rates of LH and follicle-stimulating hormone (FSH) secretion are modulated by the frequency of GnRH pulses. This study evaluated LH pulsatility in patients with idiopathic normogonadotropic oligospermia (INO) and normal men before and after clomiphene citrate (CC) administration. INO patients evidenced a lower mean LH levels (P less than 0.001), a higher mean pulse frequency (P less than 0.05) and similar pulse amplitude than normal men. CC induced in normal men a higher LH and testosterone (T) increments and increased pulse amplitude only in normal men. Estradiol (E2) showed no difference in either group. Patients with INO might evidence a hypothalamic disorder that may alter pulsatile GnRH secretion. A different response to CC in patients with INO seems to lend support to a primary hypothalamic lesion. A probable gonadotropin imbalance might alter intratesticular concentrations of T and E2 and be the cause of spermatogenic failure. |
| Databáze: | OpenAIRE |
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