Clinicopathologic study of forty-four histologically pure supratentorial oligodendrogliomas
| Autor: | John H. Suh, Dasarahally S Mohan, Richard A. Prayson, Priscilla Song |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent medicine.medical_treatment Oligodendroglioma Pathology and Forensic Medicine Older patients Glioma Biopsy Biomarkers Tumor Mitotic Index medicine Humans Nuclear atypia Child Aged Retrospective Studies Chemotherapy medicine.diagnostic_test business.industry Nuclear Proteins Supratentorial Neoplasms Antigens Nuclear Subtotal Resection General Medicine Middle Aged Prognosis medicine.disease Immunohistochemistry Gross Total Resection Survival Rate Ki-67 Antigen Female Tumor Suppressor Protein p53 business |
| Zdroj: | Annals of Diagnostic Pathology. 4:218-227 |
| ISSN: | 1092-9134 |
| DOI: | 10.1053/adpa.2000.8124 |
| Popis: | Few studies in recent years have specifically focused on pure oligodendroglial neoplasms. We retrospectively reviewed the clinicopathologic features of 44 patients with supratentorial oligodendroglioma diagnosed over a 19-year period (1974 to 1993). The study group consisted of 44 patients (age range, 8 to 69 years; median, 42 years), including 31 males. Thirty-one initially resected tumors (70%) were low grade and 13 (30%) were high grade (anaplastic). Using the St Anne-Mayo criteria for astrocytic tumors, 19 tumors (43%) were grade 2, 17 (39%) were grade 3, and 8 were (18%) grade 4. Histologic features of the tumors at initial resection included prominent nucleoli (N = 18, 41%), vascular proliferation (N = 9, 20%), necrosis (N = 6, 14%), and microcystic degeneration (N = 23, 52%). Nuclear atypia was graded as mild in 22 tumors (50%), moderate in 18 (41%), and marked in four (9%). The highest mitosis counts ranged from 0 to 10 mitotic figures (MF)/10 high-power fields (HPF) (mean, 2.4). Twelve patients (27%) had four or more MF/10 HPF. Initial surgery included gross total resection in 10 patients, subtotal resection in 16 patients, and biopsy in 14 patients. Thirty-one patients received adjuvant radiotherapy and 15 received chemotherapy. MIB-1 labeling indices ranged from 0 to 42.3 (median, 1.2 [low grade tumor median, 0.5; anaplastic tumor median, 6.2]). p53 immunostaining was observed in 18 of 43 stained tumors (41%). Overall, 5- and 10-year survival rates were 71% and 63%, respectively. The entire group had a median follow-up of 5.2 years. Age greater than 45 years ( P = .02), mitosis counts of ≥94 MF/10 HPF ( P = .0004), and MIB-1 labeling indices P = .03) were independent predictors of survival (Kaplan-Meier analysis). MIB-1 labeling indices P = .0009) was an independent predictor of disease-free survival. Low cell density ( P = .04) and low histologic grade ( P = .03) show trends with regard to being associated with longer survival. In conclusion, older patients (>45 years) or patients with tumors with an increased rate of cell proliferation generally have a worse prognosis. Although tumors of high histologic grade generally have a worse survival, the correlation was not statistically significant. Ann Diagn Pathol 4:218-227, 2000. |
| Databáze: | OpenAIRE |
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