Impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer
| Autor: | Suesada, Milena Mako, Carvalho, Heloisa de Andrade, de Albuquerque, André Luis Pereira, Salge, João Marcos, Stuart, Silvia Radwanski, Takagaki, Teresa Yae |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Exercise test Testes de função respiratória medicine.medical_treatment Breast Neoplasms Pulmonary function testing Teste de esforço 03 medical and health sciences 0302 clinical medicine Breast cancer Radioterapia DLCO Forced Expiratory Volume Pneumonite por radiação Respiratory muscle medicine Humans Lung volumes Respiratory function Prospective Studies lcsh:RC705-779 Exercise Tolerance Lymphatic Irradiation Radiotherapy business.industry Dose-Response Relationship Radiation lcsh:Diseases of the respiratory system Neoplasias da mama Middle Aged Respiratory function tests medicine.disease Respiratory Muscles Supraclavicular lymph nodes Radiation Pneumonitis Radiation therapy medicine.anatomical_structure 030228 respiratory system 030220 oncology & carcinogenesis Original Article Female Radiology Radiation pneumonitis Breast neoplasms Tomography X-Ray Computed business |
| Zdroj: | Jornal Brasileiro de Pneumologia v.44 n.6 2018 Jornal Brasileiro de Pneumologia Sociedade Brasileira de Pneumologia e Tisiologia (SBPT) instacron:SBPT Jornal Brasileiro de Pneumologia, Vol 44, Iss 6, Pp 469-476 |
| Popis: | Objective: To evaluate the impact of thoracic radiotherapy on respiratory function and exercise capacity in patients with breast cancer. Methods: Breast cancer patients in whom thoracic radiotherapy was indicated after surgical treatment and chemotherapy were submitted to HRCT, respiratory evaluation, and exercise capacity evaluation before radiotherapy and at three months after treatment completion. Respiratory muscle strength testing, measurement of chest wall mobility, and complete pulmonary function testing were performed for respiratory evaluation; cardiopulmonary exercise testing was performed to evaluate exercise capacity. The total radiotherapy dose was 50.4 Gy (1.8 Gy/fraction) to the breast or chest wall, including supraclavicular lymph nodes (SCLN) or not. Dose-volume histograms were calculated for each patient with special attention to the ipsilateral lung volume receiving 25 Gy (V25), in absolute and relative values, and mean lung dose. Results: The study comprised 37 patients. After radiotherapy, significant decreases were observed in respiratory muscle strength, chest wall mobility, exercise capacity, and pulmonary function test results (p < 0.05). DLCO was unchanged. HRCT showed changes related to radiotherapy in 87% of the patients, which was more evident in the patients submitted to SCLN irradiation. V25% significantly correlated with radiation pneumonitis. Conclusions: In our sample of patients with breast cancer, thoracic radiotherapy seemed to have caused significant losses in respiratory and exercise capacity, probably due to chest wall restriction; SCLN irradiation represented an additional risk factor for the development of radiation pneumonitis. |
| Databáze: | OpenAIRE |
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