Carbamazepine interaction with direct oral anticoagulants: help from the laboratory for the personalized management of oral anticoagulant therapy
Autor: | Stefano Lancellotti, Erica De Candia, Raimondo De Cristofaro, Leonardo Di Gennaro |
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Rok vydání: | 2019 |
Předmět: |
Drug
Personalized oral anticoagulant therapy medicine.medical_specialty Pyridines Pyridones Carbamazepin media_common.quotation_subject 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Edoxaban Atrial Fibrillation Humans Medicine Drug Interactions 030212 general & internal medicine Precision Medicine Intensive care medicine media_common Ischemic Attack Transient business.industry Potential risk Settore MED/09 - MEDICINA INTERNA Atrial fibrillation Hematology Carbamazepine medicine.disease Anti-Xa activity DOAC interaction Thiazoles chemistry Ischemic Attack Transient Concomitant Direct oral anticoagulant Anticonvulsants Drug Monitoring Factor Xa Inhibitors Pyrazoles Oral anticoagulant Apixaban Cardiology and Cardiovascular Medicine business medicine.drug |
Zdroj: | Journal of Thrombosis and Thrombolysis. 48:528-531 |
ISSN: | 1573-742X 0929-5305 |
Popis: | Current guidelines recommend caution in prescribing concomitant use of direct-acting oral anticoagulants (DOACs) and antiepileptic drugs due to drug-drug interactions leading to potential risk of DOACs subtherapeutic concentration and treatment failure. Herein we report a significant interaction between carbamazepine (CZP) and apixaban, causing subtherapeutic concentration of the drug in a patient with atrial fibrillation who had a transient ischemic attack (TIA) episode. Another anti-Xa DOAC, edoxaban, administered to the patient after TIA occurrence did not show significant interaction with CZP. In addition to confirm that cautions should be used when antiepileptic and DOACs are concomitantly prescribed, the present case also demonstrates that, in the management of certain subsets of patients who need anticoagulant treatment, measurement of DOAC plasma concentration can help guide a personalized management and avoid adverse clinical outcomes. |
Databáze: | OpenAIRE |
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