Pharmacological Activation of Peroxisome Proliferator-Activated Receptor {Delta} Increases Sphingomyelin Synthase Activity in THP-1 Macrophage-Derived Foam Cell
| Autor: | Chaogui Zhang, Chang-Hua Qu, Dongsheng Mou, Hua Yang, Juan Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Immunology Transferases (Other Substituted Phosphate Groups) Peroxisome proliferator-activated receptor Nerve Tissue Proteins Sphingomyelin synthase activity Biology GW501516 03 medical and health sciences Internal medicine Sphingomyelin synthase medicine Humans Immunology and Allergy PPAR delta Receptor Foam cell chemistry.chemical_classification Dose-Response Relationship Drug 030102 biochemistry & molecular biology Macrophages Membrane Proteins Atherosclerosis medicine.disease Sphingomyelins Thiazoles 030104 developmental biology Endocrinology Nuclear receptor chemistry biology.protein Peroxisome proliferator-activated receptor delta Foam Cells |
| Zdroj: | Inflammation. 39:1538-1546 |
| ISSN: | 1573-2576 0360-3997 |
| DOI: | 10.1007/s10753-016-0389-0 |
| Popis: | Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors, which mediate glucose and lipid homeostasis by regulating the expression of a large number of transcription factors. Sphingomyelin synthase (SMS) is a key enzyme in the synthesis of sphingomyelin (SM), and its expression and activity have been reported to be associated with atherosclerosis (AS). Although there have been many functional PPAR and SMS studies on atherosclerosis in recent years, few have investigated the correlation between the activation of PPARδ and the activity of SMS. In his study, macrophage-induced foam cells were utilized to model important pathological changes that occur in AS. The influence of PPARδ agonism by GW501516 on SMS and its product molecule SM were measured. Results indicated that the activation of PPARδ was correlated in a positive manner with the activity of SMS2, and the content of SM was dose dependently increased by GW501516. Together, this study represents the first to suggest that PPARδ activation may be a potential risk of AS through enhancing activity of SMS2. |
| Databáze: | OpenAIRE |
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