The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells
| Autor: | Lionel F. Poulin, Adrien Kissenpfennig, Sandrine Henri, Elisabeth Devilard, Bernard Malissen, Béatrice de Bovis |
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| Přispěvatelé: | Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2007 |
| Předmět: |
MESH: Spleen
MESH: Lymph Nodes Kidney Mice 0302 clinical medicine MESH: Microscopy Confocal Immunology and Allergy MESH: Animals MESH: Langerhans Cells 0303 health sciences Microscopy Confocal MESH: Dendritic Cells MESH: Kinetics integumentary system biology MESH: Bone Marrow Cells hemic and immune systems Dermis Articles Cell biology medicine.anatomical_structure Antigens Surface [SDV.IMM]Life Sciences [q-bio]/Immunology Langerhans cell Langerin MESH: Antigens Surface Immunology Bone Marrow Cells chemical and pharmacologic phenomena Spleen MESH: Antigens CD45 Article 03 medical and health sciences MESH: Mice Inbred C57BL MESH: Mannose-Binding Lectins medicine Animals Lectins C-Type MESH: Mice 030304 developmental biology Diphtheria toxin Epidermis (botany) Dendritic Cells MESH: Kidney MESH: Dermis Mice Inbred C57BL Kinetics Mannose-Binding Lectins Langerhans Cells Humanized mouse biology.protein Leukocyte Common Antigens Lymph Nodes Bone marrow Epidermis MESH: Epidermis MESH: Lectins C-Type 030215 immunology |
| Zdroj: | Poulin, L F, Henri, S, De Bovis, B, Devilard, E, Kissenpfennig, A & Malissen, B 2007, ' The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. ' Journal of Experimental Medicine, vol. 204(13), no. 13, pp. 3119-3131 . DOI: 10.1084/jem.20071724 Journal of Experimental Medicine Journal of Experimental Medicine, Rockefeller University Press, 2007, 204 (13), pp.3119-31. ⟨10.1084/jem.20071724⟩ Journal of Experimental Medicine, 2007, 204 (13), pp.3119-31. ⟨10.1084/jem.20071724⟩ The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20071724 |
| Popis: | International audience; Langerhans cells (LCs) constitute a subset of dendritic cells (DCs) that express the lectin langerin and that reside in their immature state in epidermis. Paradoxically, in mice permitting diphtheria toxin (DT)-mediated ablation of LCs, epidermal LCs reappeared with kinetics that lagged behind that of their putative progeny found in lymph nodes (LNs). Using bone marrow (BM) chimeras, we showed that a major fraction of the langerin(+), skin-derived DCs found in LNs originates from a developmental pathway that is independent from that of epidermal LCs. This pathway, the existence of which was unexpected, originates in the dermis and gives rise to langerin(+) dermal DCs (DDCs) that should not be confused with epidermal LCs en route to LNs. It explains that after DT treatment, some langerin(+), skin-derived DCs reappear in LNs long before LC-derived DCs. Using CD45 expression and BrdU-labeling kinetics, both LCs and langerin(+) DDCs were found to coexist in wild-type mice. Moreover, DT-mediated ablation of epidermal LCs opened otherwise filled niches and permitted repopulation of adult noninflammatory epidermis with BM-derived LCs. Our results stress that the langerin(+) DC network is more complex than originally thought and have implications for the development of transcutaneous vaccines and the improvement of humanized mouse models. |
| Databáze: | OpenAIRE |
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