Altered expression of glucose metabolism associated genes in a tacrolimus‑induced post‑transplantation diabetes mellitus in rat model
| Autor: | Cunzao Wu, Minmin Wu, Yong Cai, Peng Xia, Ling Zhang, Bicheng Chen, Jiao Luo, Yunqiang He, Xuehai Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty medicine.medical_treatment Gene Expression Peroxisome proliferator-activated receptor Adipose tissue Adipokine Tacrolimus Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Insulin resistance Internal medicine Diabetes mellitus Glucose Intolerance Genetics medicine Animals Insulin chemistry.chemical_classification biology business.industry Organ Transplantation General Medicine medicine.disease Rats Disease Models Animal Insulin receptor Glucose 030104 developmental biology Endocrinology Gene Expression Regulation chemistry Organ Specificity 030220 oncology & carcinogenesis biology.protein Carbohydrate Metabolism Rosiglitazone business Biomarkers Immunosuppressive Agents Signal Transduction medicine.drug |
| Zdroj: | International Journal of Molecular Medicine. |
| ISSN: | 1791-244X 1107-3756 |
| Popis: | Post‑transplantation diabetes mellitus (PTDM) is a known side effect in transplant recipients administered with immunosuppressant drugs, such as tacrolimus (Tac). Although injury of islet cells is considered a major reason for Tac‑induced PTDM, the involvement of insulin resistance in PTDM remains unknown. In the present study, expression levels of adipocytokines, glucose metabolism associated genes and peroxisome proliferator‑activated receptor (PPAR)‑γ in adipose, muscular and liver tissues from a rat model induced with Tac (1 mg/kg/day) were examined. Rats developed hyperglycemia and glucose intolerance after 10 days of Tac administration. A subgroup of diabetic rats was further treated with rosiglitazone (4 mg/kg), a PPAR‑γ activator. Adipose, muscle and liver tissues were obtained on day 15 after induction and the results demonstrated that expression levels of adipocytokines, PPAR‑γ and proteins in the insulin associated signaling pathway varied in the different groups. Rosiglitazone administration significantly improved hyperglycemia, glucose intolerance and expression levels of proteins associated with insulin signaling, as well as adipocytokines expression. The results of this study demonstrated that adipocytokines and PPAR‑γ signaling may serve important roles in the pathogenesis of Tac‑induced PTDM, which may provide a promising application in the treatment of PTDM in the future. |
| Databáze: | OpenAIRE |
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