Activation of platelets and inflammatory cytokines in male participants of an Indian Antarctic expedition
| Autor: | Brij Bhushan, Mohammad Z. Ashraf, Amit Prabhakar, A P Yadav, Lilly Ganju, S.B. Sigh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0106 biological sciences
Platelets Inflammation 010504 meteorology & atmospheric sciences Ecology business.industry 010604 marine biology & hydrobiology Aquatic Science Stress 01 natural sciences Proinflammatory cytokine Clotting time Coagulation Immunology General Earth and Planetary Sciences Medicine Antarctica Platelet Platelet activation medicine.symptom business Ecology Evolution Behavior and Systematics 0105 earth and related environmental sciences |
| Zdroj: | Polar Science. 19:146-150 |
| ISSN: | 1873-9652 |
| Popis: | Based on 12 male volunteers we investigated through blood samples at four distinct time-points if a sojourn of 90 days in the Antarctic environment induces or impels significant alterations in platelet activation and inflammatory cytokines. The levels of coagulation signatures in terms of platelet activation molecules, clotting time, clot rate, key inflammatory cytokines and coagulation-associated inflammatory markers were measured. Significant enhancement in the expression of platelet activation molecules and cytokines was observed with shortened clotting time, most prominent during the ship's approach to the continent. In conclusion, exposure to the Antarctic environment correlated with hyper activation of platelets and inflammatory cytokines, indicative of the pro-coagulative state. |
| Databáze: | OpenAIRE |
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