Pharmacotherapy Prescriptions for Relapse Prevention of Psychotic Depression After Electroconvulsive Therapy
| Autor: | Patricia Marino, Barnett S. Meyers, Dina A Patel, Ellen M. Whyte, Benoit H. Mulsant, Aristotle N. Voineskos, Anthony J. Rothschild, Alastair J. Flint, George S. Alexopoulos |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty medicine.medical_treatment Psychotic depression Relapse prevention behavioral disciplines and activities law.invention 03 medical and health sciences 0302 clinical medicine Electroconvulsive therapy Pharmacotherapy Randomized controlled trial Recurrence law mental disorders Secondary Prevention medicine Humans Pharmacology (medical) Electroconvulsive Therapy Antipsychotic Aged Retrospective Studies Aged 80 and over Depression business.industry Middle Aged medicine.disease Antidepressive Agents 030227 psychiatry Psychiatry and Mental health Regimen Psychotic Disorders Lithium Compounds Antidepressant Drug Therapy Combination Female business 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | Journal of Clinical Psychopharmacology. 41:196-199 |
| ISSN: | 1533-712X 0271-0749 |
| Popis: | Purpose/background Electroconvulsive therapy (ECT) is effective in the treatment of acute episodes of psychotic depression. However, no adequately powered studies have directly investigated the efficacy of antipsychotic pharmacotherapy in relapse prevention of psychotic depression after ECT. In the absence of such literature, we reviewed the clinical practice of 4 academic medical centers that have made research contributions in the treatment of psychotic depression over the past 20 years. Methods/procedures We reviewed medical records of patients with a diagnosis of psychotic depression who received 1 or more acute courses of ECT over the span of 3 years. Chi-square tests were used to compare pharmacotherapy prescribed at the time of completion of ECT. Findings/results A total of 163 patients received 176 courses of ECT for separate episodes of psychotic depression. The combination of an antidepressant plus an antipsychotic was the most common regimen, ranging from 61.9% to 85.5% of all prescriptions. One center added lithium in 45.5% of cases treated with the combination of an antidepressant plus an antipsychotic. An antipsychotic alone was prescribed in less than 10% of cases. An antidepressant alone or other drug combinations were rare. Implications/conclusions The combination of an antidepressant plus an antipsychotic was the most commonly prescribed regimen at the completion of ECT for relapse prevention in patients with psychotic depression acutely treated with ECT. Although this report offers a view of the clinical practice of 4 academic medical centers, it also points to the need of randomized controlled trials on continuation pharmacotherapy after treatment of psychotic depression with ECT. |
| Databáze: | OpenAIRE |
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