Adult Pilocytic Astrocytomas: A Brazilian Series
| Autor: | Gabriela Boschetti, Gustavo Lopes de Freitas Honório, Adrialdo José Santos, João Norberto Stávale, Gabriel Novaes de Rezende Batistella, Kellen Paiva Fermon, Solena Ziemer Kusma, Suzana M. F. Malheiros, Manoel Antonio de Paiva Neto |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent medicine.medical_treatment Pilocytic Astrocytomas Astrocytoma Temporal lobe Young Adult 03 medical and health sciences 0302 clinical medicine Seizures Biopsy medicine Humans Retrospective Studies Series (stratigraphy) medicine.diagnostic_test Pilocytic astrocytoma Brain Neoplasms business.industry Headache Middle Aged medicine.disease Combined Modality Therapy Gross Total Resection Surgery Radiation therapy Treatment Outcome 030220 oncology & carcinogenesis Disease Progression Female Radiotherapy Adjuvant Neurology (clinical) Cranial Irradiation business Brazil 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | World Neurosurgery. 133:e115-e120 |
| ISSN: | 1878-8750 |
| DOI: | 10.1016/j.wneu.2019.08.146 |
| Popis: | Objective Pilocytic astrocytoma (PA) is rare in adults comprising 5.1% of the primary central nervous system tumors. The aim is to describe the first Brazilian series of adult patients with PA and compare its features with the available literature. Methods We retrospectively review all patients 18 years or older with PA from our institution's database from 1991 to 2018. We analyzed information regarding clinical presentation, location, imaging features, extent of resection, adjuvant treatments, and follow-up. Results Twenty-three patients with PA were analyzed: 60.9% male; median age 26 years. The most frequent symptoms were headache (34.8%) and seizure (26.1%). Temporal and parietal lobes were the most common locations, 21.7% each. All patients underwent a surgical procedure, gross total resection in 40.9%, subtotal resection in 22.7%, and biopsy in 27.3%. Adjuvant treatment with radiotherapy was performed in 2 patients. Only 4 patients had disease progression, 2 after gross total resection and 2 after subtotal resection. They were all alive and without evidence of new progression at the last follow-up (October 2018). Median overall survival was not reached after a median follow-up time of 88.9 months. Conclusions This is the first Brazilian series regarding adults with PA, and our patients had a favorable outcome as reported in recent literature reviews. The tumor's prevalence reduces within older patients and supratentorial lesions are more frequent, especially on the temporal lobe. There was no significant relationship between location and progression, although according to the literature the extent of resection remains the most important prognostic factor. |
| Databáze: | OpenAIRE |
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