Phosphorylation of imidazo[2,1-b]thiazoles with phosphorus(III) halides in the presence of bases

Autor:	Aleksandr M. Pinchuk, Aleksandr A. Yurchenko, Evgenij V. Zarudnitskii, Anatolij S. Merkulov, Marina Semenova, Andrej A. Tolmachev
Rok vydání:	2005
Předmět:	Nitrogen atom chemistry Phosphorus Heteroatom Synthon Organic chemistry Phosphorylation chemistry.chemical_element Halide General Medicine General Chemistry Alkylation Medicinal chemistry
Zdroj:	Heteroatom Chemistry. 16:648-655
ISSN:	1098-1071 1042-7163
DOI:	10.1002/hc.20166
Popis:	The reaction of phosphorus(III) halides with 6-substituted imidazo[2,1-b]thiazoles in the presence of bases proceeds regioselectively and affords 5-phosphinoimidazo[2,1-b]thiazoles, useful synthons for the preparation of various P(III) and P(V) derivatives. 5-Phosphinoimidazo[2,1-b]thiazoles are selectively alkylated at the phosphorus or heterocyclic nitrogen atom, depending on the alkylating agent. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:648–655, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20166
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83065c0a96732fa272d937a8c1257a19 https://doi.org/10.1002/hc.20166 Zobrazit plný text záznamu