Long-term assessment of quality of life in the Intergroup Exemestane Study: 5 years post-randomisation
| Autor: | L J, Fallowfield, L S, Kilburn, C, Langridge, C F, Snowdon, J M, Bliss, R C, Coombes, S, Salvagni |
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| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
medicine.medical_specialty Libido Antineoplastic Agents Breast Neoplasms law.invention chemistry.chemical_compound breast cancer Breast cancer Quality of life Exemestane Randomized controlled trial law Surveys and Questionnaires Internal medicine Clinical endpoint Humans Medicine Aromatase Inhibitors Drug Substitution business.industry medicine.disease oestrogen receptor Surgery Androstadienes Postmenopause Clinical trial Tamoxifen Treatment Outcome Vaginal Discharge Clinical Trials Phase III as Topic Receptors Estrogen quality of life Oncology chemistry aromatase inhibitor Clinical Study Neoplasms Unknown Primary Female business exemestane Follow-Up Studies medicine.drug |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.2012.43 |
| Popis: | Background: The Intergroup Exemestane Study (IES) (ISRCTN11883920) demonstrated improved survival for postmenopausal women with ER-positive/unknown primary breast cancer who switched to exemestane after 2–3 years tamoxifen, compared with those continuing on tamoxifen to complete 5 years therapy. This was achieved without detriment to on-treatment quality-of-life (QoL). We report on- and post-treatment QoL impact in IES. Methods: A total of 582 patients from 8 countries participated in the QoL substudy. Functional Assessment of Cancer Therapy–Breast (FACT-B) and endocrine symptom subscale (ES) were completed at baseline, 3, 6, 9, 12, 18, 24, 30, 36, 48 and 60 months. The primary endpoint was FACT-B Trial Outcome Index (TOI); secondary endpoints included severity of individual endocrine symptoms. Results: Both the groups showed gradual improvement in overall QoL and lessening of total endocrine symptoms post treatment compared with baseline (P |
| Databáze: | OpenAIRE |
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