Jumping Mechanography is a Suitable Complementary Method to Assess Motor Function in Ambulatory Boys with Duchenne Muscular Dystrophy
| Autor: | Martin Rodrigues, Lena Ille, Mohamed Idriess, Astrid Blaschek, Wolfgang Müller-Felber, Rainer Rawer, Katharina Vill, Christine Müller, Sebastian Schröder |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Medical diagnostic medicine.medical_specialty Supine position Movement Duchenne muscular dystrophy Walk Test 030209 endocrinology & metabolism medicine.disease_cause Motor function 03 medical and health sciences 0302 clinical medicine Jumping Physical medicine and rehabilitation Stairs medicine Humans Ground reaction force business.industry General Medicine medicine.disease Muscular Dystrophy Duchenne Pediatrics Perinatology and Child Health Ambulatory Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Neuropediatrics. 52:455-461 |
| ISSN: | 1439-1899 0174-304X |
| DOI: | 10.1055/s-0041-1722880 |
| Popis: | Objective The number of clinical trials for Duchenne muscular dystrophy (DMD) has increased substantially lately, therefore appropriate clinical instruments are needed to measure disease progression and drug efficacy. Jumping mechanography is a medical diagnostic method for motion analysis, which allows to quantify physical parameters. In this study, we compared mechanography with timed function tests (TFTs). Methods 41 ambulatory DMD patients performed a total of 95 chair rising tests (CRT) and a total of 76 single two-legged jumps (S2LJ) on a mechanography ground reaction force platform. The results were correlated with a 6-minute walk test (6MWT) and the time required to run 10 meters, stand up from a supine position, and climb four stairs, all performed in the same setting. Results Our measurements show a high correlation between mechanography and the TFTs: S2LJ/10-m run, r = 0.62; CRT/10-m run, r = 0.61; S2LJ/standing up from supine, r = 0.48; CRT/standing up from supine, r = 0.58; S2LJ/climb four stairs, r = 0.55; CRT/climb four stairs, r = 0.51. The correlation between mechanography and the 6MWT was only moderate with r = 0.38 for S2LJ/6MWT and r = 0.39 for CRT/6MWT. Interpretation Jumping mechanography is a reliable additional method, which can be used for physical endpoint measurements in clinical trials. We confirmed our assumption, that the method provides additional information concerning performance at movement with higher power output. We suggest using the S2LJ as a first-choice tandem tool combined with the 6MWT. In patients with higher disability, the CRT is an alternative measuring method, because with the progression of the disease this is longer feasible. |
| Databáze: | OpenAIRE |
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