Levels of serum ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) predicts severity of abdominal aortic calcification in end-stage renal disease patients receiving regular dialysis
| Autor: | Qinghua Li, Xiujuan Wu, Shuijuan Shen, Zhichao Dong, Feng Di, Jianling He, Shimin Wang, Jichao Guan, Yu Wang |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Aortic Diseases Gastroenterology End stage renal disease Peritoneal dialysis Renal Dialysis medicine.artery Internal medicine medicine Humans Aorta Abdominal Pyrophosphatases Vascular Calcification Dialysis business.industry Phosphoric Diester Hydrolases Abdominal aorta Hematology medicine.disease medicine.anatomical_structure Nephrology Abdomen Kidney Failure Chronic Hemodialysis business Kidney disease Calcification |
| Zdroj: | Hemodialysis international. International Symposium on Home HemodialysisREFERENCES. 26(1) |
| ISSN: | 1542-4758 |
| Popis: | OBJECTIVE To investigate the correlation between serum ectonucleotide pyrophosphatase/phosphodiesterase-1 (ENPP1) level and severity of abdominal vascular calcification in end-stage renal disease (ESRD) patients receiving dialysis. METHODS A total of 124 patients were consecutively enrolled into the study in our local institution. Based on the Kidney Disease Improving Global Outcomes (KDIGO) guidelines and recommendations, abdomen lateral X-ray was used to determine abdominal aortic calcification score (AACS) for each patient at enrollment. Patients were divided into three groups based on AACS: no or mild calcification group, moderate calcification group, and severe calcification group. The relationships between ENPP1 levels and AACS were assessed by Spearman analysis and the value of ENPP1 in predicting severity of abdominal aortic calcification was evaluated by receiver operating characteristic (ROC). RESULTS The level of ENPP1 in dialysis patients was (7.68 ± 1.67) ng/ml. There was no significant difference in serum ENPP1 level between peritoneal dialysis patients and hemodialysis patients (p > 0.05). The AACS of dialysis patients was negatively correlated with ENPP1 value (r = -0.70). Compared to no/mild calcification patients, the levels of serum ENPP1 in patients with moderate/severe calcification were decreased significantly (p |
| Databáze: | OpenAIRE |
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